Objective To investigate the clinical effect of Gushining Capsule combined with zoledronic acid in the treatment of early- and middle-stage femoral head necrosis. Methods A total of 64 patients with early- and middle-stage femoral head necrosis were randomly divided into control group and observation group, with 32 patients in each group (38 hips in the observation group and 35 hips in the control group). The patients in the control group were given intravenous drip of zoledronic acid and oral administration of calcitriol and calcium carbonate D3, and those in the observation group were given oral administration of the traditional Chinese medicine Gushining Capsule in addition to the treatment in the control group. After 1 year of treatment, the patients were followed up at the outpatient service to observe Harris hip score and clinical outcome based on X-ray score. Results There was a significant difference in clinical outcome between the two groups (P<0.05). After 1 year of treatment, both groups had significant increases in the scores of hip joint function, deformity, range of motion, and pain (P<0.05), and compared with the control group, the observation group had significantly higher scores of hip joint function, pain, and range of motion (P<0.05). Conclusion Gushining Capsule combined with zoledronic acid, calcitriol, and calcium carbonate D3 can significantly improve the symptoms of femoral head necrosis and delay the further collapse of the femoral head.