Objective To observe the clinical efficacy of compound traditional Chinese medicine preparation, Hewei Xiaoyou Decoction, in the treatment of immature verrucous gastritis. Methods Sixty patients with immature verrucous gastritis were randomly divided into control group (n=30) and treatment group (n=30). Both groups were orally given pantoprazole, bismuth potassium citrate, amoxicillin, and clarithromycin for 2 weeks and then received oral pantoprazole for 2 weeks; additionally, the treatment group received oral Hewei Xiaoyou Decoction. The course of treatment was 28 d for both groups. Results Compared with the control group, the treatment group had significantly more improvements in syndromes and gastroscopic findings（P<0.01) and a significantly higher Helicobacter pylori eradication rate (P<0.05). Conclusion Hewei Xiaoyou Decoction has reliable efficacy in the treatment of immature verrucous gastritis.