葛根芩连结肠定位胶囊对溃疡性结肠炎大鼠疾病活动指数和结肠黏膜损伤指数的影响
DOI:
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

国家自然科学基金项目(81973488);安徽省高校协同创新项目(GXXT-2020-025);安徽中医药大学校级探索性科研项目(2021hxts03)


Effect of Gegen Qinlian Colon-specific Capsule on Disease Activity Index and Colonic Mucosal Damage Index in Rats with Ulcerative Colitis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的 在传统葛根芩连方基础上设计制备葛根芩连结肠定位释药胶囊并对其治疗溃疡性结肠炎的效果进行评价。方法 优化处方制得葛根芩连结肠定位胶囊并进行质量评价。采用2,4,6-三硝基苯磺酸复制溃疡性结肠炎大鼠模型,将模型复制成功的大鼠分成5组,即模型组、阳性对照组、葛根芩连简方组、葛根芩连全方组、葛根芩连简方结肠定位胶囊组,持续给药1周后比较给药后疾病活动指数(disease activity index, DAI)和结肠黏膜损伤指数(colonic mucosal damage index,CMDI)。结果 与模型组比较,葛根芩连简方和全方组DAI、CMDI均显著降低(P<0.05);葛根芩连简方、全方组DAI、CMDI比较,差异均无统计学意义(P>0.05);葛根芩连简方结肠定位胶囊组DAI、CMDI均显著低于葛根芩连简方和全方组(P<0.05)。结论 葛根芩连简方结肠定位胶囊可提高葛根芩连汤原方治疗溃疡性结肠炎的疗效。

    Abstract:

    Objective To prepare Gegen Qinlian Colon-specific Capsule based on the traditional Gegen Qinlian prescription, and to investigate its effect in the treatment of ulcerative colitis. Methods The traditional prescription was optimized to prepare Gegen Qinlian Colon-specific Capsule, and quality assessment was performed. A rat model of ulcerative colitis was established by 2,4,6-trinitrobenzenesulfonic acid, and after successful modeling, the rats were divided into model group, positive control group, simplified Gegen Qinlian prescription group, whole Gegen Qinlian prescription group, and simplified Gegen Qinlian prescription colon-specific Capsule group. After 1 week of continuous administration, these groups were compared in terms of disease activity index (DAI) and colonic mucosal damage index (CMDI) after administration. Results Compared with the model group, the simplified Gegen Qinlian prescription group and the whole Gegen Qinlian prescription group had significant reductions in DAI and CMDI (P<0.05), while there were no significant differences in DAI and CMDI between the simplified Gegen Qinlian prescription group and the whole Gegen Qinlian prescription group (P>0.05). The simplified Gegen Qinlian prescription colon-specific Capsule group had significantly lower DAI and CMDI than the simplified Gegen Qinlian prescription group and the whole Gegen Qinlian prescription group (P<0.05). Conclusion Colon-specific Capsule based on simplified Gegen Qinlian prescription can improve the effect of traditional Gegen Qinlian Decoction in the treatment of ulcerative colitis.

    参考文献
    相似文献
    引证文献
引用本文

吴子俊,聂湘江,方文悠,高 松,李嫚嫚,陈 圆,胡容峰.葛根芩连结肠定位胶囊对溃疡性结肠炎大鼠疾病活动指数和结肠黏膜损伤指数的影响[J].安徽中医药大学学报,2021,40(5):74-78

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2021-10-17