强力止晕汤治疗肝阳上亢兼痰湿中阻型后循环缺血性眩晕临床观察
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亳州市中医院院内课题(2017ZD002);安徽高校优秀青年骨干人才项目(gxfx2017047)


Clinical Effect of Qiangli Zhiyun Decoction in Treatment of Patients with Posterior Circulation Ischemic Vertigo with Upper Hyperactivity of Liver Yang and Interior Retention of Phlegm Dampness
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    摘要:

    目的 观察强力止晕汤治疗肝阳上亢兼痰湿中阻型后循环缺血性眩晕的临床疗效,及其对患者脑血流动力学参数的影响。方法 选取80例肝阳上亢兼痰湿中阻型后循环缺血性眩晕患者,采用随机数字表法将其分为对照组和治疗组,每组40例。对照组患者采用常规药物治疗,治疗组患者加用强力止晕汤,两组疗程均为14 d。治疗前后分别观察两组患者中医症状评分、椎-基底动脉血流改善情况,治疗14 d后及治疗后3个月的近期疗效和远期疗效,两组患者的不良反应。结果 治疗组患者治疗后眩晕、头痛、头重如裹、烦躁易怒、失眠多梦评分和总评分降低程度明显大于对照组(P<0.05),左右椎动脉、基底动脉平均血流速度升高程度和左右椎动脉、基底动脉搏动指数降低程度均明显大于对照组(P<0.05)。治疗组的近期疗效和远期疗效均明显优于对照组(P<0.05)。两组不良反应(轻度胆红素异常、胃肠道反应、心慌)的总发生率差异无统计学意义(P>0.05)。结论 强力止晕汤对肝阳上亢兼痰湿中阻型后循环缺血性眩晕有较好的临床疗效。

    Abstract:

    Objective To investigate the clinical effect of Qiangli Zhiyun Decoction in the treatment of patients with posterior circulation ischemic vertigo with upper hyperactivity of liver Yang and interior retention of phlegm dampness, as well as its effect on cerebral hemodynamic parameters. Methods A total of 80 patients with posterior circulation ischemic vertigo with upper hyperactivity of liver Yang and interior retention of phlegm dampness were divided into control group and treatment group using a random number table, with 40 patients in each group. The patients in the control group were given conventional medication, and those in the treatment group were given Qiangli Zhiyun Decoction; the course of treatment was 14 days for both groups. Traditional Chinese medicine (TCM) symptom score and vertebrobasilar arterial blood flow were observed before and after treatment; short- and long-term clinical outcomes were observed after 14 days of treatment and at 3 months after treatment; adverse reactions were evaluated in both groups. Results After treatment, compared with the control group, the treatment group had significantly greater reductions in the total score and the scores of TCM symptoms such as dizziness, headache, head heavy as if swathed, dysphoria and irritability, and insomnia and dreaminess (P<0.05), as well as significantly greater increases in mean blood flow velocity of the left vertebral artery, the right vertebral artery, and the basilar artery and significantly greater reductions in pulsatility index of these arteries (P<0.05). The treatment group had significantly better short- and long-term clinical outcomes than the control group (P<0.05). There was no significant difference in the overall incidence rate of adverse reactions (mild bilirubin abnormality, gastrointestinal reactions, and palpitation) between the two groups (P>0.05). Conclusion Qiangli Zhiyun Decoction has a good clinical effect in the treatment of posterior circulation ischemic vertigo with upper hyperactivity of liver Yang and interior retention of phlegm dampness.

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王 艳,谢道俊,马奎军,凡启涛,孟 玉,杨 贤,朱继民.强力止晕汤治疗肝阳上亢兼痰湿中阻型后循环缺血性眩晕临床观察[J].安徽中医药大学学报,2021,40(5):28-31

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  • 在线发布日期: 2021-10-17