Objective To investigate the influencing factors for the clinical effect of Xiaochaihu Decoction combined with psychological intervention in patients with somatoform disorders (SFD). Methods The single-blind sampling method was used to select the patients with SFD who were treated in the outpatient service and inpatient department of The First Affiliated Hospital of Guangxi University of Chinese Medicine. Values were assigned for the data including age, compliance, SFD severity, course of treatment, frequency of psychological intervention, course of the disease, occupation, traditional Chinese medicine (TCM) syndrome type, and treatment modality, and a logistic regression analysis was used to investigate related factors. Results The univariate analysis showed that age, compliance, course of the disease, SFD severity, course of treatment, frequency of psychological intervention, TCM syndrome type, and treatment modality were associated with clinical outcome in the patients with SFD (P<0.05), and the logistic regression analysis showed that SFD severity was the most important influencing factor for the clinical effect of Xiaochaihu Decoction combined with cognitive behavioral therapy in the patients with SFD (odds ratio = 5.675, P<0.05). Conclusion Xiaochaihu Decoction combined with cognitive behavioral therapy is an effective method for the treatment of SFD, and related influencing factors should be taken seriously to improve the clinical effect of this treatment.