黄枳胶囊治疗肠燥阴亏夹瘀型糖尿病性便秘30例
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安徽中医药大学校级探索性科研项目(2016ts035)


Clinical Effect of Huangzhi Capsule in Treatment of Diabetic Constipation with Intestinal Dryness, Yin Insufficiency, and Stasis: An Analysis of 30 Cases
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    摘要:

    目的 观察黄枳胶囊治疗糖尿病性便秘的临床疗效及对患者血浆中P物质(substance P,SP)、生长抑素(somatostatin,SS)和胰高血糖素(glucagon,GC)等胃肠激素的影响。方法 将符合纳入标准的60例糖尿病性便秘患者随机分为治疗组、对照组各30例,对照组给予基础治疗联合枸缘酸莫沙必利片治疗;治疗组予以基础治疗联合黄枳胶囊治疗,两组均治疗1个月。观察两组患者治疗前后血浆SP、SS、GC水平,稳态模型- 胰岛素抵抗(homeostasis model- insulin resistance,HOMA- IR)指数,中医证候评分,临床疗效以及不良反应发生率。结果 与治疗前比较,治疗后两组患者SP水平均显著升高(P<0.05),SS、GC水平均显著下降(P<0.05);两组患者SP、SS、GC、HOMA- IR水平差值比较,差异均有统计学意义(P<0.05)。治疗后两组患者中医证候评分均较治疗前显著降低(P<0.05),治疗组降低更为明显(P<0.05)。两组患者临床疗效分布比较,差异有统计学意义(P<0.05)。两组不良反应的总发生率比较,差异有统计学意义(χ2=5.455,P=0.020)。结论 在常规降糖治疗基础上加用黄枳胶囊,可以显著缓解临床症状,调节患者胃肠激素的异常分泌,降低血糖,改善胰岛素抵抗。

    Abstract:

    Objective To investigate the clinical effect of Huangzhi Capsule in the treatment of diabetic constipation and its effect on the plasma levels of the gastrointestinal hormones including substance P (SP), somatostatin (SS), and glucagon (GC). Methods A total of 60 patients with diabetic constipation who met the inclusion criteria were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the control group were given basic treatment and mosapride dispersible tablets, and those in the treatment group were given basic treatment and Huangzhi Capsule. The course of treatment was 1 month for both groups. The two groups were observed in terms of the plasma levels of SP, SS, and GC, homeostasis model assessment of insulin resistance (HOMA- IR), traditional Chinese medicine (TCM) syndrome score, clinical outcome, and incidence rate of adverse reactions before and after treatment. Results After treatment, both groups had a significant increase in SP (P<0.05) and significant reductions in SS and GC (P<0.05), and there were significant differences in SP, SS, GC, and HOMA- IR between the two groups (P<0.05). After treatment, both groups had a significant reduction in TCM syndrome score (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05). There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05). There was a significant difference in the overall incidence rate of adverse reactions between the two groups (χ2=5.455, P=0.020). Conclusion Huangzhi Capsule combined with conventional hypoglycemic therapy can significantly alleviate clinical symptoms, regulate the abnormal secretion of gastrointestinal hormones, reduce blood glucose, and improve insulin resistance.

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张礼玉,支晶晶,陈晓雯.黄枳胶囊治疗肠燥阴亏夹瘀型糖尿病性便秘30例[J].安徽中医药大学学报,2021,40(3):21-25

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  • 在线发布日期: 2021-06-16