通督调神针刺法对血管性轻度认知障碍患者血清脑源性神经营养因子和血浆同型半胱氨酸的影响
Effect of Tongdu Tiaoshen Acupuncture on Serum Brain-derived Neurotrophic Factor and Plasma Homocysteine in Patients with Vascular Mild Cognitive Impairment
  
DOI:
中文关键词:  通督调神针刺法  血管性轻度认知障碍  简易智力状态检查量表  蒙特利尔认知评估量表  脑源性神经营养因子  同型半胱氨酸
英文关键词:Tongdu Tiaoshen acupuncture  Vascular mild cognitive impairment  Montreal Cognitive Assessment  Mini-Mental State Examination  Brain-derived neurotrophic factor  Homocysteine
基金项目:安徽省自然科学基金项目(1708085MHZ00)
作者单位
白 琳,程红亮,张闻东,沈志强 安徽中医药大学第二附属医院安徽 合肥 230061 
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中文摘要:
      目的 观察通督调神针刺法对血管性轻度认知障碍患者的疗效,以及对血清脑源性神经营养因子(brain derived neural nutrition factor,BDNF)、血浆同型半胱氨酸(homocysteine, Hcy)水平的影响。方法 将61例血管性轻度认知障碍患者随机分为治疗组(31例)和对照组(30例),对照组患者口服药物多奈哌齐治疗2个月,治疗组除口服多奈哌齐外还予通督调神针刺法治疗4个疗程。采用简易智力状态检查(mini-mental state examination,MMSE)量表、蒙特利尔认知评估(Montreal cognitive assessment,MoCA)量表评价患者治疗前后认知水平变化,采用酶联免疫吸附法检测血清BDNF水平,循环酶法检测血浆Hcy水平。结果 与治疗前比较,治疗后两组患者MMSE评分、MoCA评分均明显增加(P<0.05);治疗组与对照组MMSE和MoCA评分差值比较,差异均有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后血清BDNF水平显著升高,血浆Hcy水平显著降低,差异均有统计学意义(P<0.05);治疗组血清BDNF水平升高程度、血浆Hcy水平降低程度均显著大于对照组(P<0.05)。两组基于MMSE评分的疗效比较,治疗组优于对照组(P<0.05)。结论 通督调神针刺能够提升血管性轻度认知功能障碍患者的认知功能评分,提高相关细胞因子的表达水平,降低相关危险因素的影响。
英文摘要:
      Objective To investigate the therapeutic effect of Tongdu Tiaoshen acupuncture in patients with vascular mild cognitive impairment and its effect on serum brain-derived neurotrophic factor (BDNF) and plasma homocysteine (Hcy). Methods A total of 61 patients with vascular mild cognitive impairment were randomly divided into treatment group with 31 patients and control group with 30 patients. The patients in the control group were given oral donepezil for two months, and those in the treatment group were given Tongdu Tiaoshen acupuncture for 4 courses in addition to oral donepezil. Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate the change in cognitive level after treatment, ELISA was used to measure the serum level of BDNF, and enzymatic cycling assay was used to measure plasma Hcy. Results After treatment, both groups had significant increases in MMSE and MoCA scores (P<0.05), and there were significant differences between the two groups in the changes in MMSE and MoCA scores after treatment (P<0.05). After treatment, both groups had a significant increase in the serum level of BDNF and a significant reduction in the plasma level of Hcy (P<0.05), and compared with the control group, the treatment group had a significantly greater increase in serum BDNF and a significantly greater reduction in plasma Hcy (P<0.05). Based on MMSE score, the treatment group had a significantly better clinical outcome than the control group (P<0.05). Conclusion For patients with vascular mild cognitive impairment, Tongdu Tiaoshen acupuncture can improve their cognitive function score, increase the expression of related cytokines, and reduce the impact of related risk factors.
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