黄芪桂枝五物汤加味联合神经营养药治疗原发性股外侧皮神经炎30例
Clinical Effect of Jiawei Huangqi Guizhi Wuwu Decoction Combined With Neurotrophic Drugs in Treatment of Primary Lateral Femoral Cutaneous Neuropathy: An Analysis of 30 Cases
  
DOI:
中文关键词:  黄芪桂枝五物汤  神经营养药  股外侧皮神经炎
英文关键词:Huangqi Guizhi Wuwu Decoction  Neurotrophic drug  Lateral femoral cutaneous neuropathy
基金项目:国家自然科学基金项目(81874389)
作者单位
王雪洁,谢道俊 1.安徽中医药大学安徽 合肥 2300122.安徽中医药大学第一附属医院安徽 合肥 230031 
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中文摘要:
      目的 观察黄芪桂枝五物汤加味联合神经营养药治疗原发性股外侧皮神经炎(lateral femoral cutaneous neuropathy,LFCN)的临床疗效。方法 将60例原发性LFCN患者随机分为对照组和治疗组,每组30例。对照组口服甲钴胺分散片、维生素B1片、维生素B6片,治疗组在对照组治疗基础上采用黄芪桂枝五物汤加味;治疗前后分别采用视觉模拟评分法(visual analogue scale,VAS)评价疼痛、麻木程度,采用肌电图诱发电位仪检测患侧股外侧皮神经的感觉传导速度(sensory conduction velocity,SCV),观察两组临床疗效。结果 两组患者治疗后疼痛、麻木评分均较治疗前明显下降(P<0.05),且治疗组下降程序更为明显(P<0.05)。治疗后两组患者外侧皮神经SCV值均较治疗前明显增加(P<0.05),且治疗组SCV增加程度明显大于对照组(P<0.05)。两组患者临床疗效比较,差异有统计学意义(P<0.05)。结论 黄芪桂枝五物汤加味联合神经营养药可减轻原发性LFCN的疼痛、麻木症状,提高神经传导速度,具有较好的临床疗效。
英文摘要:
      Objective To investigate the clinical effect of Jiawei Huangqi Guizhi Wuwu Decoction combined with neurotrophic drugs in the treatment of primary lateral femoral cutaneous neuropathy (LFCN). Methods A total of 60 patients with LFCN were randomly divided into control group and treatment group, with 30 patients in each group. The patients in the control group were given oral mecobalamin dispersible tablets, vitamin B1 tablets, and vitamin B6 tablets, and those in the treatment group were given Jiawei Huangqi Guizhi Wuwu Decoction in addition to the treatment in the control group. Visual Analogue Scale (VAS) was used to evaluate the degree of pain and numbness and an electromyography evoked potential meter was used to measure the sensory conduction velocity (SCV) of the lateral femoral cutaneous nerve before and after treatment, and clinical outcome was observed after treatment. Results Both groups had significant reductions in the scores of pain and numbness after treatment (P<0.05), and the treatment group had significantly better scores than the control group (P<0.05). After treatment, both groups had a significant increase in the SCV value of the lateral cutaneous nerve (P<0.05), and the treatment group had a significantly greater increase in SCV than the control group (P<0.05). There was a significant difference in clinical outcome between the two groups (P<0.05). Conclusion Jiawei Huangqi Guizhi Wuwu Decoction combined with neurotrophic drugs has a good clinical effect in the treatment of primary LFCN and can relieve pain and numbness and increase nerve conduction velocity.
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