The medication history of Radix Adenophorae is more than 2600 years longer than Radix Glehniae, and Radix Adenophorae is more abundant and widely distributed than Radix Glehniae. Compared with Radix Glehniae, Radix Adenophorae has more functions, with a greater increase in the number of indications. It is recommended that Pharmacopoeia of The Peoples Republic of China should record Adenophora stricta, Adenophora hunanensis, and Adenophora stricta Miq. subsp. sessilifolia Hong as the botanical origin of the traditional Chinese medicine Radix Adenophorae to expand the origin of Radix Adenophorae. Related departments should strengthen the protection of the wild species of Radix Glehniae and establish a germplasm resources bank for Glehnia littoralis. When selecting traditional Chinese medicine to clear away lung-heat and nourish lung-Yin in clinical practice, clinicians should focus on Radix Adenophorae, with the support of Radix Glehniae.