定坤丹联合来曲唑治疗肾虚证多囊卵巢综合征不孕症临床疗效观察
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安徽省自然科学基金项目(1808085MH265)。


Clinical Effect of Dingkun Pill Combined with Letrozole in Treatment of Infertility with Kidney Deficiency Due to Polycystic Ovary Syndrome
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    摘要:

    目的 观察定坤丹联合来曲唑治疗肾虚证多囊卵巢综合征(polycystic ovary syndrome, PCOS)不孕症临床疗效。方法 选取经预处理后的肾虚证PCOS不孕症患者60例,随机分为治疗组和对照组,每组30例。对照组单独服用来曲唑,治疗组在对照组基础上加服定坤丹,比较两组患者月经周期第5天、第10天和肌肉注射人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)诱发排卵当日雌二醇水平、子宫内膜厚度以及排卵情况、妊娠情况和临床疗效。结果 两组月经周期第5天子宫内膜厚度差异无统计学意义(P>0.05);治疗组月经周期第10天、肌肉注射hCG诱发排卵当日雌二醇水平、子宫内膜厚度均高于对照组(P<0.05);治疗组排卵情况、妊娠情况以及临床疗效均优于对照组(P<0.05)。结论 定坤丹联合来曲唑治疗肾虚证PCOS不孕症有显著优势。

    Abstract:

    Objective To investigate the clinical effect of Dingkun Pill combined with letrozole in the treatment of infertility with kidney deficiency due to polycystic ovary syndrome (PCOS). Methods A total of 60 pretreated patients with infertility with kidney deficiency due to PCOS were enrolled and randomly divided into treatment group and control group, with 30 patients in each group. The patients in the control group were given letrozole alone, and those in the treatment group were given Dingkun Pill in addition to the treatment in the control group. The two groups were compared in terms of level of estradiol and endometrial thickness on days 5 and 10 of menstrual cycle and on the day of intramuscular injection of human chorionic gonadotropin (hCG) to induce ovulation, ovulation and pregnancy conditions, and clinical outcome. Results There was no significant difference in endometrial thickness on day 5 of menstrual cycle between the two groups (P>0.05), and compared with the control group, the treatment group had significantly higher level of estradiol and endometrial thickness on day 10 of menstrual cycle and on the day of intramuscular injection of hCG to induce ovulation (P<0.05). The treatment group had significantly better conditions of ovulation and pregnancy than the control group (P<0.05). Conclusion Dingkun Pill combined with letrozole has great advantages in the treatment of infertility with kidney deficiency due to PCOS.

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储继军,王肖莉,王瑞雪.定坤丹联合来曲唑治疗肾虚证多囊卵巢综合征不孕症临床疗效观察[J].安徽中医药大学学报,2020,39(3):27-31

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  • 在线发布日期: 2020-06-04