十三味玉泉丸治疗早期2型糖尿病疗效观察
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湖北省卫生计生委2016-2017年度中医药中西医结合科研一般项目(编号44)


Clinical Effect of Thirteen-flavor Yuquan Pill in Treatment of Early-stage Type 2 Diabetes Mellitus
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    摘要:

    目的 观察十三味玉泉丸治疗早期2型糖尿病的临床疗效。方法 将100例早期2型糖尿病患者随机分为对照组和治疗组各50例,对照组采用二甲双胍缓释片联合阿卡波糖片口服降血糖,治疗组采用十三味玉泉丸口服降血糖,两组疗程均为3个月。比较两组治疗后空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-h postprandial blood glucose,2hPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FINS)、胰岛素分泌指数(homeostasis model assessment beta-cell function,HOMA-β)、胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)、体质量指数(body mass index,BMI)、不良反应发生率。结果 与治疗前比较,两组患者治疗后FPG、2hPG、HOMA-IR、BMI降低,FINS、HOMA-β显著升高,差异均有统计学意义(P<0.05);治疗组患者治疗前后HOMA-β、HOMA-IR差值显著大于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 十三味玉泉丸治疗早期2型糖尿病疗效确切,能很好地降血糖,改善胰岛β细胞功能,减少胰岛素抵抗,减轻体质量,且无明显不良反应。

    Abstract:

    Objective To investigate the clinical effect of Thirteen-flavor Yuquan Pill in the treatment of early-stage type 2 diabetes mellitus (T2DM). Methods A total of 100 patients with early-stage T2DM were randomly divided into control group and treatment group, with 50 patients in each group. The patients in the control group were treated with oral metformin sustained-release tablets and acarbose tablets to reduce blood glucose, and those in the treatment group were treated with oral Thirteen-flavor Yuquan Pill to reduce blood glucose. The course of treatment was 3 months for both groups. The two groups were compared in terms of fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), glycosylated hemoglobin (HbA1C), fasting insulin (FINS), homeostasis model assessment β-cell function (HOMA-β), homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), and incidence rate of adverse events after treatment. Results Both groups had significant reductions in FPG, 2hPG, HOMA-IR, and BMI and significant increases in FINS and HOMA-β after treatment (P<0.05), and compared with the control group, the treatment group had significantly greater changes in HOMA-β and HOMA-IR after treatment (P<0.05). There was no significant difference in the incidence rate of adverse events between the two groups (P>0.05). Conclusion Thirteen-flavor Yuquan Pill has a marked clinical effect in the treatment of early-stage T2DM and can effectively reduce blood glucose, improve the function of pancreatic β cells, alleviate insulin resistance, and reduce body weight, with little adverse effect.

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刘慧君,肖 进,陈 锋.十三味玉泉丸治疗早期2型糖尿病疗效观察[J].安徽中医药大学学报,2020,39(1):29-31

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  • 在线发布日期: 2020-01-17