300例冠心病合并2型糖尿病患者中医证型与血脂、血糖和心脏超声结果的关系
Association of Traditional Chinese Medicine Syndrome Type with Blood Lipids, Blood Glucose, and Echocardiographic Findings in Patients with Coronary Heart Disease and Type 2 Diabetes: An Analysis of 300 Cases
  
DOI:
中文关键词:  冠心病  2型糖尿病  中医证型  血糖  血脂  心脏超声  同型半胱氨酸  C-反应蛋白
英文关键词:Coronary heart disease  Type 2 diabetes  Traditional Chinese medicine syndrome type  Blood glucose  Blood lipids  Echocardiography  Homocysteine  C-reactive protein
基金项目:安徽省卫生计生委中医药科研课题项目(2016zy72);安徽中医药大学探索性科研项目(2016ts047)
作者单位
邵正斌,黄 平,夏铭蔚,梁国庆,戚先伟,左 强,戴小华 1.安徽中医药大学第一附属医院安徽 合肥 2300312.安徽省中医药科学院心血管研究所安徽 合肥 230031 
摘要点击次数: 1220
全文下载次数: 1536
中文摘要:
      目的 探究冠心病合并2型糖尿病患者中医证型与血脂、血糖和心脏超声诊断结果等临床指标的关系,为中医辨证客观化提供临床证据。方法 共纳入300例冠心病合并2型糖尿病患者,观察并比较不同证型患者的血糖[空腹血糖(fasting plasma glucose, FPG)、餐后2 h血糖(2-hour postprandial blood glucose, 2hPG)、糖基化血红蛋白A1c(glycosylated hemoglobin, HbA1c)]、血脂[三酰甘油(triglyceride, TG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)]、血同型半胱氨酸(homocysteine, HCY)、血C-反应蛋白(C-reactive protein, CRP)及心脏超声诊断结果[(左室内径(left ventricular diameter, LVD)、左室射血分数(left ventricular ejection fraction, LVEF)]。结果 不同证型的冠心病合并2型糖尿病患者FPG、HbA1c比较,差异有统计学意义(P<0.05);阳虚血瘀证患者TC、TG水平最高,而气虚痰阻证患者LDL-C最高;不同证型患者2hPG、HDL-C、CRP水平比较,差异无统计学意义(P>0.05)。气阴两虚证、气虚痰瘀证、阳虚血瘀证患者HCY、LVD水平依次递增,而LVEF依次递减。结论 不同证型冠心病合并2型糖尿病患者血糖、血脂和心脏超声结果等临床指标存在一定差异。
英文摘要:
      Objective To investigate the association of traditional Chinese medicine (TCM) syndrome type with blood lipids, blood glucose, and echocardiographic findings in patients with coronary heart disease and type 2 diabetes, and to provide clinical evidence for objective TCM syndrome differentiation. Methods A total of 300 patients with coronary heart disease and type 2 diabetes were enrolled. The patients with different TCM syndrome types were compared in terms of blood glucose [fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), and glycosylated hemoglobin (HbA1c)], blood lipids [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], blood homocysteine (HCY), blood C-reactive protein (CRP), and echocardiographic findings [left ventricular diameter (LVD) and left ventricular ejection fraction (LVEF)]. Results There were significant differences in FPG and HbA1c between the patients with different TCM syndrome types (P<0.05). The patients with Yang deficiency and blood stasis syndrome had the highest levels of TC and TG, while those with Qi deficiency and phlegm stagnation syndrome had the highest level of LDL-C. There were no significant differences in 2hPG, HDL-C, and CRP between the patients with different TCM syndrome types (P>0.05). There were gradual increases in HCY and LVD and a gradual reduction in LVEF in the patients with deficiency of both Qi and Yin, those with Qi deficiency and phlegm stasis, and those with Yang deficiency and blood stasis. Conclusion There are certain differences in blood glucose, blood lipids, and echocardiographic findings between patients with coronary heart disease and type 2 diabetes who have different TCM syndrome types.
查看全文  查看/发表评论  下载PDF阅读器
关闭