益肾活血解毒汤对原发性高血压患者同型半胱胺酸含量和凝血功能的影响
Effect of Yishen Huoxue Jiedu Decoction on the Level of Homocysteine and Coagulation Function in Patients with Primary Hypertension
  
DOI:
中文关键词:  益肾活血解毒汤  高血压  同型半胱氨酸  凝血功能
英文关键词:Yishen Huoxue Jiedu Decoction  Hypertension  Homocysteine  Coagulation function
基金项目:国家自然科学基金项目(81373774);安徽省卫生和计划生育委员会中医药领军人才培养对象专项项目(中医药发展秘〔2018〕23号);安徽中医药大学青年基金项目(2015fy002)
作者单位
何 佳,程晓昱 安徽中医药大学第一附属医院安徽 合肥 230031 
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中文摘要:
      目的 观察益肾活血解毒汤对原发性高血压患者同型半胱氨酸(homocysteine,HCY)含量及凝血功能的影响。方法 选取60例原发性高血压患者,随机分为研究组和对照组各30例。两组患者均接受常规降压方案,研究组患者加用益肾活血解毒汤,连服2周。观察两组患者治疗前后24 h动态血压(24 hour ambulatory blood pressure,24hABP)、HCY和凝血功能[D 二聚体(D dimer,D D)、纤维蛋白原(fibrinogen,Fib)、部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)]。结果 两组患者治疗后24 h平均收缩压和平均舒张压均较治疗前明显下降(P<0.05),但两组治疗前后24 h平均收缩压和平均舒张压差值的差异无统计学意义(P>0.05)。两组患者治疗后TT、APTT均较治疗前显著延长(P<0.05),Fib、D D、HCY显著降低(P<0.05),且研究组治疗后APTT延长程度和Fib、D D、HCY降低程度显著大于对照组(P<0.05)。结论 在有效降压基础上加用益肾活血解毒汤可以更好地改善血液高凝状态、降低HCY。
英文摘要:
      Objective To investigate the effect of Yishen Huoxue Jiedu Decoction on the level of homocysteine (HCY) and coagulation function in patients with primary hypertension. Methods A total of 60 patients with primary hypertension were randomly divided into observation group and control group, with 30 patients in each group. The patients in the control group were given conventional antihypertensive treatment alone, and those in the observation group were given Yishen Huoxue Jiedu Decoction for two consecutive weeks in addition to the treatment in the control group. The two groups were observed in terms of 24 hour ambulatory blood pressure (24hABP), HCY, and coagulation function [D dimer (D D), fibrinogen (Fib), activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT)] before and after treatment. Results Both groups had significant reductions in mean 24 hour systolic and diastolic blood pressure after treatment (P<0.05), and there was no significant difference in the degree of reduction between the two groups (P>0.05). After treatment, both groups had significant increases in TT and APTT and significant reductions in Fib, D D, and HCY (P<0.05), and the observation group had significantly greater increases of APTT and reductions of Fib, D D and HCY than the control group (P<0.05). Conclusion Yishen Huoxue Jiedu Decoction combined with effective antihypertensive treatment can improve blood hypercoagulability and reduce HCY.
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