益气补肾化瘀方治疗早期糖尿病肾病临床观察
Clinical Effect of Yiqi Bushen Huayu Prescription in Treatment of Early Diabetic Nephropathy
  
DOI:
中文关键词:  糖尿病肾病  气阴亏虚夹瘀证  尿白蛋白排泄率  尿蛋白定量
英文关键词:Diabetic nephropathy  Syndrome of deficiency of both Qi and Yin with stasis  Urine albumin excretion rate  24-Hour urinary protein
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周 鑫,陆俊峰,温 泉 六安市中医院安徽 六安 237000 
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中文摘要:
      目的 观察益气补肾化瘀方治疗早期糖尿病肾病的临床疗效。方法 将64例早期糖尿病肾病患者分为对照组和治疗组,每组32例。对照组服用缬沙坦,治疗组服用缬沙坦和益气补肾化瘀方,疗程均为12周。比较两组治疗前后中医证候积分、血糖、血压、尿白蛋白排泄率(urinary albumin excretion rate,UAER)、24h尿蛋白定量(24-hour urine protein, 24hUP)、尿白蛋白与尿肌酐比值(urine albumin to creatinine ratio,UACR)变化情况。结果 治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗组治疗后中医证候积分显著下降(P<0.05),治疗组治疗后中医证候积分降低值显著大于对照组(P<0.05)。与治疗前比较,两组患者治疗后空腹血糖(fasting plasma glucose,FPG)、收缩压、UAER、24hUP、UACR均显著降低(P<0.05),治疗组治疗后FPG、UAER、24hUP、UACR降低值显著大于对照组(P<0.05)。结论 益气补肾化瘀方可提高早期糖尿病肾病患者的临床疗效,减少尿蛋白。
英文摘要:
      Objective To investigate clinical effect of Yiqi Bushen Huayu prescription in the treatment of early diabetic nephropathy. Methods A total of 64 patients with early diabetic nephropathy were divided into treatment group and control group, with 32 patients in each group. The patients in the control group were given valsartan alone, and those in the treatment group were given valsartan combined with Yiqi Bushen Huayu prescription. The course of treatment was 12 weeks for both groups. The two groups were compared in terms of the changes in traditional Chinese medicine (TCM) syndrome score, fasting plasma glucose (FPG), blood pressure, urine albumin excretion rate (UAER), 24-hour urinary protein (24hUP), and urinary albumin-to-creatinine ratio (UACR) after treatment. Results The treatment group had a significantly better clinical outcome than the control group (P<0.05). After treatment, the treatment group had a significant reduction in TCM syndrome score (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05). After treatment, both groups had significant reductions in FPG, systolic blood pressure, UAER, 24hUP, and UACR (P<0.05), and the treatment group had significantly greater reductions in FPG, UAER, 24hUP, and UACR than the control group (P<0.05). Conclusion Yiqi Bushen Huayu prescription can improve the clinical outcome of patients with early diabetic nephropathy and reduce urinary protein.
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