芦黄颗粒治疗动脉粥样硬化60例
Clinical Effect of Luhuang Granule in Treatment of Atherosclerosis: An Analysis of 60 Cases
  
DOI:
中文关键词:  芦黄颗粒  动脉粥样硬化  动脉功能  血脂  血液流变学  炎症因子
英文关键词:Luhuang Granule  Atherosclerosis  Arterial function  Blood lipid  Hemorheology  Inflammatory factor
基金项目:江苏省自然科学基金项目(BK20151355)
作者单位
朱 燕,黄 辉,顾万建,何静静,刘福明 南京中医药大学附属医院江苏 南京 210029 
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中文摘要:
      目的 观察芦黄颗粒对动脉粥样硬化患者动脉功能、血脂、血液流变性及血清炎症因子的影响。方法 将符合纳入标准的动脉粥样硬化患者60例随机分为治疗组及对照组,每组30例;治疗组在标准化西医治疗基础上联用芦黄颗粒,对照组仅予西医标准化治疗,治疗8周后比较两组患者中医证候积分、颈动脉内膜中层厚度、阻力指数、极速成像脉搏波传导速度、血脂、血液流变性、血清炎症因子(C- 反应蛋白、白细胞介素- 6、肿瘤坏死因子- α)及肝肾功能的变化。结果 ①治疗后两组中医证候积分均有改善(P<0.05),且治疗组明显优于对照组(P<0.05);②治疗后两组双侧颈动脉极速成像脉搏波传导速度、阻力指数均有改善(P<0.05),且治疗组优于对照组(P<0.05),双侧颈动脉内膜中层厚度治疗前后差异无统计学意义(P>0.05);③治疗后两组血脂、血清炎症因子均有改善(P<0.05),且治疗组优于对照组(P<0.05);④治疗后两组血液流变学指标均有改善(P<0.05),且治疗组明显优于对照组(P<0.05);⑤两组治疗后肝肾功能均无明显异常。结论 芦黄颗粒可通过改善患者动脉功能、血液流变性,调节血脂及血清炎症因子水平,延缓动脉粥样硬化的进程。
英文摘要:
      Objective To investigate the effect of Luhuang Granule on arterial function, blood lipids, hemorheology, and serum inflammatory factors in patients with atherosclerosis. Methods A total of 60 patients with atherosclerosis who met the inclusion criteria were enrolled and randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given Luhuang Granule combined with standard Western medicine treatment, and those in the control group were given standard Western medicine treatment alone. After 8 weeks of treatment, the two groups were compared in terms of the changes in traditional Chinese medicine (TCM) syndrome score, carotid intima- media thickness and resistance index, ultrafast pulse wave velocity, blood lipids, hemorrheology, inflammatory factors C- reactive protein (CRP), interleukin- 6 (IL- 6), and tumor necrosis factor- α (TNF- α)], and hepatic and renal function. Results Both groups had a significant improvement in TCM syndrome score after treatment (P<0.05), and the treatment group had a significantly better score than the control group (P<0.05). Both groups had significant improvements in the ultrafast pulse wave velocity and resistance index of both carotid arteries after treatment (P<0.05), and the treatment group had significantly better improvements than the control group (P<0.05); there was no significant change in the carotid intima- media thickness of both carotid arteries after surgery (P>0.05). Both groups had significant improvements in blood lipids and inflammatory factors after treatment (P<0.05), and the treatment group had significantly better improvements than the control group (P<0.05). Both groups had significant improvements in hemorheological indices after treatment (P<0.05), and the treatment group had significantly better improvements than the control group (P<0.05). No abnormalities in hepatic and renal function were observed after treatment. Conclusion Luhuang Granule can delay the progression of atherosclerosis by improving arterial function and hemorrheology, and regulating serum levels of blood lipids and inflammatory factors.
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