益气健脾通便方联合乳果糖治疗慢传输型便秘肺脾气虚证临床观察
Clinical Effect of Yiqi Jianpi Tongbian Prescription Combined with Lactulose in Treatment of Slow Transit Constipation with Syndrome of Qi Deficiency of Lung and Spleen
  
DOI:
中文关键词:  益气健脾通便方  肺脾气虚型  慢传输型便秘
英文关键词:Yiqi Jianpi Tongbian Prescription  Qi deficiency of lung and spleen  Slow transit constipation
基金项目:安徽省卫生计生委中医药科研计划项目(2016zy02);安徽省高校自然科学研究项目(KJ2016A396);“十三五”医疗卫生重点专科建设项目(卫科教秘〔2016〕658号)
作者单位
余文美,王建民,方笑丽 1.安徽中医药大学研究生院安徽 合肥 2300122.安徽中医药大学第一附属医院安徽 合肥 230031 
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中文摘要:
      目的 观察益气健脾通便方联合乳果糖治疗慢传输型便秘(slow transit constipation,STC)肺脾气虚证的临床疗效,观察其对血清神经肽Y(neuropeptide Y,NPY)、一氧化氮(nitric oxide,NO)含量的影响。方法 将62例STC肺脾气虚证患者分为观察组和对照组,每组31例,两组均给予一般基础治疗,对照组在此基础上单纯服用乳果糖口服液治疗,治疗组服用益气健脾通便方和乳果糖治疗,两组疗程均为1个月,观察比较两组治疗前后临床症状积分,大便性状积分,肠传输试验,血清NPY、NO含量的变化情况。结果 两组治疗前后临床症状积分、大便性状积分比较,差异均有统计学意义(P<0.05);观察组在排便困难、排便时间、排便频率、腹胀及大便性状的改善方面优于对照组(P<0.05)。两组48 h、72 h标记物排出数及72 h排出率比较,差异均有统计学意义(P<0.05);观察组治疗后标记物排出数大于对照组,72 h排出率明显增加(P<0.05)。两组患者治疗后血清NPY、NO含量均较治疗前降低,差异有统计学意义(P<0.05),且观察组下降更明显(P<0.05)。结论 益气健脾通便方联合乳果糖治疗肺脾气虚型STC效果确切,优于单纯乳果糖治疗。
英文摘要:
      Objective To investigate the clinical effect of Yiqi Jianpi Tongbian Prescription combined with lactulose in the treatment of slow transit constipation (STC) with syndrome of Qi deficiency of lung and spleen and its effect on the serum levels of neuropeptide Y (NPY) and nitric oxide (NO). Methods A total of 62 patients with STC with syndrome of Qi deficiency of lung and spleen were divided into observation group and control group, with 31 patients in each group. In addition to basic treatment, the patients in the control group were given lactulose oral liquid, and those in the observation group were given Yiqi Jianpi Tongbian Prescription combined with lactulose. The course of treatment was one month for both groups. The two groups were compared in terms of the changes in symptom score, stool property, colonic transit test results, and serum levels of NPY and NO after treatment. Results After treatment, both groups had significant changes in symptom score and stool property score (P<0.05), and compared with the control group, the observation group had significantly greater improvements in difficult defecation, defecation time and frequency, abdominal distension, and stool property (P<0.05). There were significant differences between the two groups in the number of markers in stool at 48 and 72 hours and 72- hour excretion rate (P<0.05), and compared with the control group after treatment, the observation group had significantly better number of markers in stool and 72- hour excretion rate (P<0.05). Both groups had significant reductions in the serum levels of NPY and NO after treatment (P<0.05), and the observation group had significantly greater reductions than the control group (P<0.05). Conclusion Yiqi Jianpi Tongbian Prescription combined with lactulose has a good clinical effect in the treatment of STC with syndrome of Qi deficiency of lung and spleen, with a better clinical effect than lactulose alone.
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