“发汗”与非“发汗”丹参中10种活性成分含量测定及其质量的主成分分析
Content Determination of Ten Active Components in Salvia miltiorrhiza With or Without Sweating Treatment and Quality Evaluation Based on a Principal Component Analysis
  
DOI:
中文关键词:  丹参  发汗  高效液相色谱法  含量比较  主成分分析
英文关键词:Salvia miltiorrhiza  Sweating  High-performance liquid chromatography  Content comparison  Principal component analysis
基金项目:安徽道地中药材品质提升协同创新中心项目(皖教科〔2013〕2号);中医药行业科研专项安徽种植种苗基地建设项目(201207002);安徽省重点研究与开发计划项目(1704a0802145)
作者单位
王 婷,于 凡,李国转,邱 镇,陈卫东,彭代银,俞年军,王国凯 1.安徽中医药大学药学院安徽 合肥 2300122.安徽道地中药材品质提升协同创新中心安徽 合肥 2300123.安徽中医药大学药物代谢研究所,安徽 合肥 230012 
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中文摘要:
      目的 考察“发汗”丹参与非“发汗”丹参中10种活性成分含量的差异,对“发汗”与非“发汗”两种加工方法进行综合评价。方法 将同一批次丹参鲜品随机分为两组,分别进行“发汗”与非“发汗”处理,对两组丹参中10种活性成分(丹参素、原儿茶酸、原儿茶醛、咖啡酸、异阿魏酸、迷迭香酸、丹酚酸B、隐丹参酮、丹参酮Ⅰ、丹参酮ⅡA)进行含量测定并采用主成分分析法对两组丹参质量进行分析。结果 “发汗”后丹参酚酸类成分和丹参酮ⅡA含量上升,隐丹参酮和丹参酮Ⅰ的含量略有下降;主成分分析结果表明,“发汗”处理后基于效应成分的综合评分更高。结论 “发汗”丹参质量优于非“发汗”丹参。
英文摘要:
      Objective To investigate the differences in the content of 10 active components between Salvia miltiorrhiza with or without sweating treatment, and to perform a comprehensive evaluation of sweating and non-sweating processing methods. Methods The same batch of fresh products of Salvia miltiorrhiza were randomly divided into two groups and were given sweating and non-sweating treatment, respectively. The content of 10 active components (danshensu, protocatechuic acid, protocatechuic aldehyde, caffeic acid, isoferulic acid, rosmarinic acid, salvianolic acid B, cryptotanshinone, tanshinone Ⅰ, and tanshinone ⅡA) was determined, and a principal component analysis was performed for quality evaluation. Results Compared with the non-sweating group, the sweating group had increases in the content of salvianolic acid and tanshinone ⅡA and slight reductions in the content of cryptotanshinone and tanshinone Ⅰ. The principal component analysis showed that there was an increase in comprehensive score based on active component after sweating treatment. Conclusion Salvia miltiorrhiza with sweating treatment has better quality than that without sweating treatment.
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