补肾活血法对自然流产血栓前状态早期干预研究
Early Intervention Effect of Kidney-Tonifying and Blood-Activating Therapy on Prothrombotic State of Patients with Spontaneous Abortion
  
DOI:
中文关键词:  自然流产  血栓前状态  肾虚血瘀证  补肾活血法  凝血功能
英文关键词:Spontaneous abortion  Prothrombotic state  Syndrome of kidney deficiency and blood stasis  Kidney-tonifying and blood-activating therapy  Coagulation function
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作者单位
杨 璇,张晓莉,余小琴,李伟莉 1.安徽中医药大学第三附属医院妇科安徽 合肥 2300612.安徽中医药大学第一附属医院妇科安徽 合肥 230031 
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中文摘要:
      目的 观察补肾活血法对自然流产血栓前状态的临床疗效。方法 将50例自然流产血栓前状态患者随机分为治疗组和对照组,每组25例。对照组口服阿司匹林肠溶片治疗,治疗组在对照组治疗基础上服用补肾活血中药。观察治疗前后患者血清D-二聚体(D-dimer, D-D)、纤维蛋白降解产物(fibrinogen degradation product, FDP)水平、凝血功能相关实验室指标,并对患者妊娠结局进行评价。结果 与治疗前比较,两组治疗后FDP、纤维蛋白原(fibrinogen, Fib)显著降低(P<0.05),活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)均显著延长(P<0.05)。治疗组Fib降低值和TT升高值显著大于对照组(P<0.05)。对照组治疗后19例妊娠,成功妊娠11例,妊娠成功率为57.9%;治疗组妊娠20例,成功妊娠18例,妊娠成功率为90.0%。两组妊娠成功率比较,差异有统计学意义(P<0.05)。结论 补肾活血法协同阿司匹林能明显改善自然流产血栓前状态,提高患者妊娠成功率。
英文摘要:
      Objective To investigate the clinical effect of kidney-tonifying and blood-activating therapy in the treatment of prothrombotic state in patients with spontaneous abortion. Methods A total of 50 patients with spontaneous abortion and a prothrombotic state were randomly divided into treatment group and control group, with 25 patients in each group. The patients in the control group were given oral aspirin enteric-coated tablets, and those in the treatment group were given kidney-tonifying and blood-activating traditional Chinese medicine in addition to the treatment in the control group. Serum levels of D-dimer (D-D), fibrinogen degradation product (FDP), and coagulation markers were measured, and pregnancy outcome was evaluated. Results After treatment, both groups had significant reductions in FDP and fibrinogen (Fib) (P<0.05) and significant increases in activated partial thromboplastin time and thrombin time (TT) (P<0.05), and compared with the control group, the treatment group had a significantly greater reduction in Fib and a significantly greater increase in TT (P<0.05). In the control group, 19 patients became pregnant after treatment, among whom 11 had successful pregnancy, with a success rate of 57.9%; in the treatment group, 20 patients became pregnant after treatment, among whom 18 had successful pregnancy, with a success rate of 90.0%; there was a significant difference in the success rate of pregnancy between the two groups (P<0.05). Conclusion Kidney-tonifying and blood-activating therapy combined with aspirin can significantly improve prothrombotic state in patients with spontaneous abortion and increase the success rate of pregnancy.
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