Abstract:Objective To optimize the extraction process of Lingzhu Shaodan Decoction. Methods With the comprehensive score of tyrosinase inhibition rate and clearance rate of 1,1-diphenyl-2-picrylhydrazyl free radicals as an assessment index, the L9 (34) orthogonal test was used to optimize the extraction process of Lingzhu Shaodan Decoction. Results The optimal extraction process of Lingzhu Shaodan Decoction was a solid-liquid ratio of 1∶7 g/mL, an extraction time of 1.5 hours, an extraction temperature of 80 ℃, and one time of extraction. Conclusion The extraction process of Lingzhu Shaodan Decoction optimized based on whitening effect is stable and feasible and can provide a basis for the research and development of whitening cosmetics based on Lingzhu Shaodan Decoction.