Objective To establish a determination method for arsenic content in Shexiang Jiegu Capsule. Methods Graphite furnace atomic absorption spectrophotometry was used to measure arsenic content in Shexiang Jiegu Capsule. Results There was a good linear relationship between arsenic content and absorbance within the range of 0-100 ng/mL, and the linear equation was y=0.002 23x+0.004 79(r=0.996). The average recovery rate was 97.0%. Conclusion Graphite furnace atomic absorption spectrophotometry is simple, accurate, and sensitive and can be used to measure arsenic content in Shexiang Jiegu Capsule.