“贺氏三通法”治疗2型糖尿病周围神经病变的随机对照研究
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北京市医院管理局重点医学专业发展计划项目(ZYLX201412)


Clinical Effect of Hes Acupuncture-Moxibustion Three Removing Obstruction Methods in Treatment of Type 2 Diabetic Peripheral Neuropathy: A Randomized Controlled Trial
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    摘要:

    目的 观察“贺氏三通法”之“温通法”治疗2型糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床疗效和安全性。方法 按照随机化分组原则,将57例DPN患者随机分为观察组和对照组,其中观察组29例,对照组28例。纳入病例均接受基础治疗,包括糖尿病健康教育、糖尿病饮食、运动锻炼;在此基础上口服降糖药物和(或)皮下注射胰岛素。治疗期间所有病例均禁用抗凝剂、扩血管药物。观察组病例同时采用“贺氏三通法”之“温通法”针刺方案,对照组采用假穴浅刺法,两组均每星期治疗2次,连续治疗8周。治疗前、治疗8周后分别评价DPN临床症状总积分、密西根糖尿病神经病评分(Michigan Diabetic Neuropathy Score, MDNS)和不良反应。结果 治疗后两组临床症状总积分、MDNS均较治疗前显著降低(P<0.05)。观察组治疗后MDNS降低程度明显大于对照组(P<0.05),而临床症状总积分降低程度与对照组比较,差异无统计学意义(P>0.05)。观察组临床疗效明显优于对照组(P<0.05)。两组均无不良反应发生。结论 “贺氏三通法”可明显改善DPN的临床症状,且无明显不良反应。

    Abstract:

    Objective To investigate the clinical effect and safety of the warm-removing obstruction method, one of Hes acupuncture-moxibustion three removing obstruction methods, in the treatment of diabetic peripheral neuropathy (DPN) of type 2 diabetes. Methods A total of 57 patients with DPN were randomly divided into observation group with 29 patients and control group with 28 patients. All patients were given basic treatment, including health education on diabetes, diabetic diet, and exercise, combined with oral hypoglycemic agents and/or subcutaneously injected insulin, and anticoagulants and vasodilators were prohibited during treatment. In addition, the patients in the observation group were given acupuncture using the warm-removing obstruction method, and those in the control group were given superficial acupuncture at sham acupoints. Treatment was given twice a week, and the course of treatment was 8 consecutive weeks for both groups. Total symptom score of DPN and Michigan Diabetic Neuropathy Score (MDNS) were evaluated before treatment and after 8 weeks of treatment, and adverse reactions were evaluated after 8 weeks of treatment. Results Both groups had significant reductions in total symptom score and MDNS after treatment (P<0.05). Compared with the control group after treatment, the observation group had a significantly greater reduction in MDNS (P<0.05), while there was no significant difference in the reduction in total symptom score between the two groups (P>0.05). The observation group had a significantly better clinical outcome than the control group (P<0.05). No adverse reactions were observed in both groups. Conclusion Hes acupuncture-moxibustion three removing obstruction methods can significantly improve the clinical symptoms of DPN, with little adverse effect.

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程金莲,肖 爽,宣雅波,王 济,易京红.“贺氏三通法”治疗2型糖尿病周围神经病变的随机对照研究[J].安徽中医药大学学报,2018,37(6):46-49

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  • 在线发布日期: 2018-12-04