肠炎Ⅰ号方治疗大肠湿热型溃疡性结肠炎疗效观察
DOI:
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

安徽省科技攻关项目(1501041151)


Clinical Efficacy of Enteritis No. 1 Prescription in Treatment of Ulcerative Colitis of Large Intestine Damp-Heat Type
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的 观察肠炎Ⅰ号方治疗大肠湿热型溃疡性结肠炎(ulcerative colitis,UC)的临床疗效及其对血清炎性因子含量的影响。方法 将60例大肠湿热型UC患者分为对照组和治疗组,每组30例,对照组患者给予美沙拉嗪栓1.0 g塞肛,治疗组患者给予肠炎Ⅰ号方保留灌肠。每晚1次,1个月为1个疗程,治疗2个疗程后采用ELISA法分别检测两组患者血清白介素 (interleukin,IL)-6和肿瘤坏死因子 (tumor necrosis factor,TNF)-α含量,观察两组患者治疗前后Sutherland疾病活动指数变化及临床疗效。结果 两组患者临床疗效分布比较,差异有统计学意义(P<0.05)。治疗后两组血清IL-6、TNF-α含量,Sutherland 疾病活动指数均较治疗前明显降低(P<0.05);两组治疗前后IL-6、TNF-α含量,Sutherland 疾病活动指数差值比较,差异均有统计学意义(P<0.05)。结论 肠炎Ⅰ号方保留灌肠治疗UC疗效显著,可以明显降低患者血清IL-6、TNF-α水平。

    Abstract:

    Objective To investigate the clinical efficacy of Enteritis No. 1 prescription in the treatment of ulcerative colitis (UC) of large intestine damp-heat type and its effects on serum levels of inflammatory factors. Methods Sixty patients with UC of large intestine damp-heat type were equally and randomly divided into control group and treatment group. The control group received 1.0 g of mesalazine suppositories, while the treatment group received Enteritis No. 1 prescription retention enema. Both groups received two courses of treatment (once every night, 1 month for a course). After two courses of treatment, serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay. The serum levels of IL-6 and TNF-α, changes in Sutherland Disease Activity Index (SDAI), and treatment outcomes were compared between the two groups. Results There was a significant difference in the distribution of treatment outcomes between the two groups (P<0.05). After treatment, both groups showed significantly reduced serum levels of IL-6 and TNF-α and SDAI (P<0.05). However, the treatment group had significantly greater reductions in the above indices than the control group (P<0.05). Conclusion Enteritis No.1 prescription retention enema can significantly reduce serum levels of IL-6 and TNF-α and has good clinical efficacy in the treatment of UC of large intestine damp-heat type.

    参考文献
    相似文献
    引证文献
引用本文

杜 骏,王建民,唐 冉,唐 昆,方笑丽,孙 杭.肠炎Ⅰ号方治疗大肠湿热型溃疡性结肠炎疗效观察[J].安徽中医药大学学报,2018,37(6):28-31

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2018-12-04