红蓝光联合丹参酮胶囊治疗寻常型痤疮疗效观察及其作用机制研究
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Clinical Effect of Redblue Light Combined with Tanshinone Capsule in Treatment of Acne Vulgaris and Related Mechanism of Action
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    摘要:

    目的 观察红蓝光联合丹参酮胶囊治疗寻常型痤疮的临床疗效及对患者血清白细胞介素(interleukin,IL)-1β、IL-6水平的影响。方法 将80例有典型临床症状的寻常型痤疮患者分为治疗组和对照组,每组40例。治疗组采用红蓝光联合丹参酮胶囊治疗,对照组采用丹参酮胶囊治疗,对皮损进行评分,观察临床疗效,采用ELISA法检测患者治疗前后血清IL-1β、IL-6的含量。结果 两组治疗后皮疹积分与治疗前比较,差异均有统计学意义(P<0.05);两组患者治疗前后皮疹积分差值比较,差异有统计学意义(P<0.05)。两组患者临床疗效分布比较,差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后血清IL-1β、IL-6含量均显著减少(P<0.05);两组治疗前后血清IL-1β、IL-6含量差值比较,差异均有统计学意义(P<0.05)。结论 红蓝光联合丹参酮胶囊治疗寻常型痤疮临床疗效优于丹参酮胶囊,其机制可能是通过调节患者免疫反应来实现的。

    Abstract:

    Objective To investigate the clinical effect of redblue light combined with Tanshinone Capsule in the treatment of acne vulgaris and its effect on the serum levels of interleukin-1β (IL-1β) and interleukin6 (IL-6). Methods A total of 80 patients with acne vulgaris who had typical clinical symptoms were divided into treatment group and control group, with 40 patients in each group. The patients in the treatment group were given redblue light combined with Tanshinone Capsule, and those in the control group were given Tanshinone Capsule alone. The skin lesion score was determined, and the distribution of clinical outcomes was observed. ELISA was used to measure the serum levels of IL-1β and IL-6 before and after treatment.Results Both groups had a significant improvement in skin lesion score after treatment(P<0.05),and there was no significant difference in the degree of improvement between the two groups(P<0.05).There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05). Both groups showed significant reductions in the serum levels of IL-1β and IL-6 after treatment (P<0.05),and the treatment group had significantly greater reductions than the control group(P<0.05).Conclusion Red-blue light combined with Tanshinone Capsule has a better clinical effect than Tanshinone Capsule alone in the treatment of acne vulgaris, possibly by regulating patients' immune response.

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严 静,滕浦陵.红蓝光联合丹参酮胶囊治疗寻常型痤疮疗效观察及其作用机制研究[J].安徽中医药大学学报,2018,37(4):20-23

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  • 在线发布日期: 2018-08-09