峏山杨氏保胎汤联合黄体酮治疗早期先兆流产20例
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Clinical Effect of Ershan Yangs Baotai Decoction Combined with Progesterone in Treatment of Early Threatened Abortion: An Analysis of 20 Cases
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    摘要:

    目的 观察峏山杨氏保胎汤联合黄体酮治疗早期先兆流产的疗效,并从血清性激素水平探讨其作用机制。方法 以2012年1月至2016年12月门诊保胎的40例早期先兆流产患者为研究对象,将其随机分为观察组与对照组,每组20例。对照组患者接受黄体酮肌肉注射,观察组患者加服峏山杨氏保胎汤。观察两组临床疗效和中医症状改善情况,以及不同时点血清β-绒毛膜促性腺激素(beta-human chorionic gonadotropin, β-HCG)、孕酮(progesterone, P)和雌二醇(estradiol, E2)水平。结果 观察组临床疗效优于对照组,但差异无统计学意义(P>0.05)。观察组在降低中医主症积分、次症积分和总积分方面明显优于对照组(P<0.05)。随着孕周增加,两组血清β-HCG、P、E2水平逐渐增加,治疗2周末,两组血清β-HCG、P、E2水平均较治疗前明显升高(P<0.05)。治疗1、2、3周末,观察组血清E2水平均明显高于对照组(P<0.05)。结论 峏山杨氏保胎汤有助于提高黄体酮治疗早期先兆流产的疗效,其机制可能与调节血清性激素水平有关。

    Abstract:

    Objective To investigate the clinical effect of Ershan Yangs Baotai Decoction combined with progesterone in the treatment of early threatened abortion and possible mechanism of action based on serum sex hormone level. Methods A total of 40 patients with early threatened abortion who were treated in the outpatient service from January 2012 to December 2016 were enrolled and randomly divided into observation group and control group, with 20 patients in each group. The patients in the control group were given intramuscular injection of progesterone, and those in the observation group were given Ershan Yangs Baotai Decoction in addition to the treatment for the control group. The clinical outcome and relief of traditional Chinese medicine (TCM) symptoms were observed in both groups, and the serum levels of beta-human chorionic gonadotropin (β-HCG), progesterone (P), and estradiol (E2) were measured at different time points. Results The observation group had a better clinical outcome than the control group (P>0.05). Compared with the control group, the observation group had significantly greater reductions in primary TCM symptom score, minor TCM symptom score, and total score (P<0.05). The serum levels of β-HCG, P, and E2 gradually increased with the increase in gestational weeks, and after 2 weeks of treatment, both groups had significant increases in the serum levels of β-HCG, P, and E2 (P<0.05). After 1, 2, and 3 weeks of treatment, the observation group had a significantly higher serum level of E2 than the control group (P<0.05). Conclusion Ershan Yangs Baotai Decoction combined with progesterone can improve the clinical outcome of early threatened abortion, possibly by regulating the serum levels of sex hormones.

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张东鸣.峏山杨氏保胎汤联合黄体酮治疗早期先兆流产20例[J].安徽中医药大学学报,2017,36(3):29-32

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  • 在线发布日期: 2017-06-05