丹参注射液体外对格列喹酮血浆蛋白结合率的影响
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国家自然科学基金项目(81102682);安徽省高等学校自然科学基金项目(KJ2015A130)


n VitroEffect of Salvia miltiorrhiza Injection on Plasma Protein Binding Rate of Gliquidone
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    摘要:

    目的 考察丹参注射液体外对格列喹酮血浆蛋白结合率的影响。方法 采用平衡透析法和高效液相色谱法,分别在有无丹参注射液的情况下对格列喹酮血浆蛋白结合率进行测定。结果 格列喹酮高浓度(12.6 μg/mL)、中浓度(6.3 μg/mL)、低浓度(1.26 μg/mL)的血浆蛋白结合率差异无统计学意义(P>0.05)。在含有高浓度(750 mg/mL)、中浓度(375 mg/mL)、低浓度(75 mg/mL)丹参注射液时,格列喹酮(12.6 μg/mL)的血浆蛋白结合率分别为(82.6±3.11)%、(87.3±9.80)%、(92.6±4.21)%。在含有高浓度丹参注射液时,格列喹酮血浆蛋白结合率显著降低(P<0.05)。结论 在临床剂量下,丹参注射剂不会影响格列喹酮血浆蛋白结合率。

    Abstract:

    Objective To investigate the in vitro effect of Salvia miltiorrhiza injection on the plasma protein binding rate of gliquidone. Methods Equilibrium dialysis and high- performance liquid chromatography were used to measure the plasma protein binding rate of gliquidone with the presence or absence of Salvia miltiorrhiza injection. Results There were no significant differences in plasma protein binding rate between high, medium, and low concentrations of gliquidone (12.6, 6.3, and 1.26 μg/mL, respectively) (P>0.05). With the presence of the high- , medium- , and low- concentration Salvia miltiorrhiza injections (750, 375, and 75 mg/mL, respectively), the plasma protein binding rates of gliquidone were(82.6±3.11), (87.3±9.80)%, and (92.6±4.21)%, respectively. With the presence of high- concentration Salvia miltiorrhiza injection, there was a significant reduction in the plasma protein binding rate of gliquidone (P<0.05). Conclusion Salvia miltiorrhiza injection at the dose used in clinical practice does not affect the plasma protein binding rate of gliquidone.

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张 瑞,杨 晔,王 炜,倪 妮,尹登科.丹参注射液体外对格列喹酮血浆蛋白结合率的影响[J].安徽中医药大学学报,2017,36(2):72-75

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  • 在线发布日期: 2017-04-07