仙茅苷对电刺激应激小鼠神经精神活动的影响
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国家自然科学基金项目(81673716,81601181);安徽高校省级自然科学研究项目(KJ2016A417);安徽中医药大学人才引进基金项目(2015RC001)


Effect of Curculigoside on Nervous and Mental Activities in Mice with Stress Induced by Electrical Stimulation
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    目的 探讨仙茅苷对电刺激应激小鼠记忆、抑郁、焦虑样行为的影响。方法 采用电刺激前和电刺激后两个时间点给药,通过恐惧记忆测试、强迫游泳及旷场实验,观察仙茅苷(每日20 mg/kg,腹腔注射,7 d)对电刺激应激小鼠恐惧记忆、抑郁及焦虑等神经活动的影响。结果 与对照组小鼠比较,电刺激前给药不影响小鼠在受到电击24 h及48 h后的凝滞时间;而电刺激后给药的小鼠在给药结束后再次测得的凝滞时间较对照组显著提高(P<0.05)。在电刺激后给药的实验中,仙茅苷能显著缩短小鼠不动时间(P<0.05);电刺激前给药组亦有相同趋势,但差异并无统计学意义(P>0.05)。电刺激前后给药均不影响小鼠在中央格停留时间比(P>0.05);与对照组比较,药物组电刺激前后给药具有提高小鼠运动总路程的趋势,但差异均无统计学意义(P>0.05)。结论 仙茅苷具有改善电刺激应激小鼠抑郁的症状及抑制记忆退化的作用。

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    Objective To investigate the effect of curculigoside on the memory, depression, and anxiety in mice with stress induced by electrical stimulation. Methods The mice were treated with curculigoside before and after electrical stimulation. The fear memory test, forced swimming test, and open field test were performed to observe the effect of curculigoside (injected at 20 mg/kg daily for 7 days) on fear memory, depression, and anxiety.Results Compared with those in the control group, the mice treated with curculigoside before electrical stimulation showed no changes in freezing time at 24 and 48 hours after electrical stimulation, while the mice treated with curculigoside after electrical stimulation had a significant increase in freezing time as measured again after administration (P<0.05). The mice treated with curculigoside after electrical stimulation had significantly reduced immobility time (P<0.05), while the mice treated with curculigoside before electrical stimulation had nonsignificantly reduced immobility time (P>0.05). Administration before or after electrical stimulation did not affect the duration of time spent in the central square (P>0.05). Compared with the control group, the mice treated before and after electrical stimulation tended to have an increase in the total distance of movement (P>0.05). Conclusion Curculigoside can improve the symptoms of depression and inhibit memory decay in mice with stress induced by electrical stimulation.

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陈 慧,李君耀,李庆林,朱国旗.仙茅苷对电刺激应激小鼠神经精神活动的影响[J].安徽中医药大学学报,2017,36(1):63-66

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  • 在线发布日期: 2017-01-15