Abstract:Objective To investigate the effect of curculigoside on the memory, depression, and anxiety in mice with stress induced by electrical stimulation. Methods The mice were treated with curculigoside before and after electrical stimulation. The fear memory test, forced swimming test, and open field test were performed to observe the effect of curculigoside (injected at 20 mg/kg daily for 7 days) on fear memory, depression, and anxiety.Results Compared with those in the control group, the mice treated with curculigoside before electrical stimulation showed no changes in freezing time at 24 and 48 hours after electrical stimulation, while the mice treated with curculigoside after electrical stimulation had a significant increase in freezing time as measured again after administration (P<0.05). The mice treated with curculigoside after electrical stimulation had significantly reduced immobility time (P<0.05), while the mice treated with curculigoside before electrical stimulation had nonsignificantly reduced immobility time (P>0.05). Administration before or after electrical stimulation did not affect the duration of time spent in the central square (P>0.05). Compared with the control group, the mice treated before and after electrical stimulation tended to have an increase in the total distance of movement (P>0.05). Conclusion Curculigoside can improve the symptoms of depression and inhibit memory decay in mice with stress induced by electrical stimulation.