Objective To investigate the clinical efficacy of Jialiu Capsule combined with Euthyrox in the treatment of Hashimotos thyroiditis complicated by thyroid nodules. Methods A prospective design was used, and 30 outpatients with Hashimotos thyroiditis and thyroid nodules were given iodine-free diet and oral Jialiu Capsule combined with Euthyrox; a continuous administration for 3 months was considered as one course of the treatment. Clinical efficacy and the changes in immunological indicators （anti-thyroid peroxidase antibody，TPOAb；antithyroglobulin antibody，TgAb) and thyroid ultrasound parameters (the volume and thickness of the left and right lobes of thyroid gland and the maximum diameter and cross-sectional area of thyroid nodules) were observed. Results Of all patients, none were cured, 28 showed response to the treatment, and 2 showed no response; the overall response rate was 93.33%. After treatment, TPOAb and TgAb decreased significantly (P<0.05), the thickness and volume of the right lobe of thyroid gland were reduced significantly (P<0.05), and there were no significant changes in the thickness and volume of the left lobe of thyroid gland, as well as the maximum diameter and maximum cross-sectional area of thyroid nodules (P>0.05). Conclusion Jialiu Capsule can significantly reduce the levels of thyroid-related antibodies and alleviate enlargement of the right lobe of the thyroid gland, and its effect on enlargement of the left lobe of the thyroid gland and thyroid nodules awaits further investigation.