甲瘤胶囊治疗桥本甲状腺炎合并结节30例
Clinical Efficacy of Jialiu Capsule for Treatment of Hashimotos Thyroiditis Complicated by Thyroid Nodules
  
DOI:
中文关键词:  桥本甲状腺炎  甲状腺结节  甲瘤胶囊
英文关键词:Hashimoto's thyroiditis  Thyroid nodule  Jialiu Capsule
基金项目:天津市中医药管理局中西医结合科研课题(13119)
作者单位
王 环,陈 洁 1.天津中医药大学研究生院天津 3001932.天津市第一中心医院天津 300192 
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中文摘要:
      目的 观察甲瘤胶囊联合优甲乐治疗桥本甲状腺炎合并结节的临床疗效。 方法 使用前瞻性设计方法,对门诊30例桥本甲状腺炎合并结节患者给予忌碘饮食、甲瘤胶囊联合优甲乐口服治疗,连续服用3个月为1个疗程。观察临床疗效及治疗前后免疫学指标(抗甲状腺过氧化物酶抗体,anti-thyroid peroxidase antibody,TPOAb;抗甲状腺球蛋白抗体,thyroglobulin antibodies,TgAb)、甲状腺超声指标(甲状腺左右叶体积、甲状腺左右叶厚度、结节的最大直径和最大横截面积)的变化。 结果 显效0例,有效28例,无效2例,总有效率为93.33%。与治疗前比较,治疗后TPOAb和TgAb显著降低(P<0.05),甲状腺右叶厚度和体积较治疗前显著缩小(P<0.05),甲状腺左叶厚度和体积以及甲状腺结节最大直径和最大横截面积均无明显变化(P>0.05)。 结论 甲瘤胶囊可明显降低甲状腺相关抗体水平和减轻甲状腺右叶肿大,对甲状腺左叶肿大和结节的影响有待进一步临床研究。
英文摘要:
      Objective To investigate the clinical efficacy of Jialiu Capsule combined with Euthyrox in the treatment of Hashimotos thyroiditis complicated by thyroid nodules. Methods A prospective design was used, and 30 outpatients with Hashimotos thyroiditis and thyroid nodules were given iodine-free diet and oral Jialiu Capsule combined with Euthyrox; a continuous administration for 3 months was considered as one course of the treatment. Clinical efficacy and the changes in immunological indicators (anti-thyroid peroxidase antibody,TPOAb;antithyroglobulin antibody,TgAb) and thyroid ultrasound parameters (the volume and thickness of the left and right lobes of thyroid gland and the maximum diameter and cross-sectional area of thyroid nodules) were observed. Results Of all patients, none were cured, 28 showed response to the treatment, and 2 showed no response; the overall response rate was 93.33%. After treatment, TPOAb and TgAb decreased significantly (P<0.05), the thickness and volume of the right lobe of thyroid gland were reduced significantly (P<0.05), and there were no significant changes in the thickness and volume of the left lobe of thyroid gland, as well as the maximum diameter and maximum cross-sectional area of thyroid nodules (P>0.05). Conclusion Jialiu Capsule can significantly reduce the levels of thyroid-related antibodies and alleviate enlargement of the right lobe of the thyroid gland, and its effect on enlargement of the left lobe of the thyroid gland and thyroid nodules awaits further investigation.
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