川芎嗪对大鼠脑缺血再灌注损伤的保护作用
THE PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ACUTE CEREBRAL ISCHEMIA REPERFUSION INJURY IN RATS
  
DOI:10.3969/j.issn.1000-2219.2013.00.000
中文关键词:  川芎嗪  脑缺血  脂质过氧化  中分子物质  一氧化氮  丙二醛
英文关键词:Ligustrazine,Brain ischemin,Lipid peroxidation,Middle molecule substance,Nitric oxide,Malondialdehyde
基金项目:
汪远金  申国明  王钦茂
安徽中医学院中西医结合系
摘要点击次数: 6301
全文下载次数: 142
中文摘要:
      探讨川芎嗪对大鼠脑缺血再灌注损伤的保护作用及机制。方法:采用大鼠双侧颈总动脉闭塞的不完全性脑缺血再灌注模型,测定血浆中一氧化氮及中分子物质总量和脑组织中丙二醛含量变化。结果:川芎嗪显增加缺血大鼠血浆中NO含量,降低MMS总量和组织中MDA的含量,以及降低血比粘度。
英文摘要:
      Objective:the study is to observed the protective effects of ligustrazine on acute brain ischemia reperfusion injury in rats.Method:the content of plasma nitric oxide (NO) and middle molecule substance(MMS) and the content of brain tissue malondialdehyde(MDA) were detected using the models of incomplete brain ischemia reperfuing in rates by closing bilateral common carotid arteries.Result:ligustrazine could significantly increase nitric oxide content,reduced middle molecule sudstance and malondialdehyd content and viscosity of blood injury in rats.Conclusion:the protective effects of ligustrazine on cerebral ischemia injury may be related to its antilipid peroxidation and increased NO content and also decreased MMS level.
查看全文  查看/发表评论  下载PDF阅读器
关闭