Abstract:Objective To investigate the clinical effect of Jiawei Simiao Yongan Decoction in the treatment of acute radiation esophagitis. Methods A total of 57 patients with acute radiation esophagitis with heat-toxin congestion and excessivenesswere randomly divided into observation group with 29 patients and control groupwith 28 patients. In addition to the conventional treatment of gargle with sodium chloride injection 100 mL+ vitamin B120.25 mg once a day, the patients in the observation group were given oral administration of Jiawei Simiao Yongan Decoction (formulated granules), and those in the control group were given oral administration of Kangfuxin Liquid; the course of treatment was 6 weeks for both groups. The two groups were compared in terms of Visual Analogue Scale(VAS) score, traditional Chinese medicine (TCM) symptom score, and Karnofsky Performance Scale (KPS) score of swallowing pain, and clinical outcome was evaluated for both groups. Results After treatment, both groups had a significant reduction in VAS score (P<0.05), and the observation group had a significantly greater reduction than the control group (P<0.05); the control group had a significant reduction in KPS score after treatment (P<0.05), while the observation group had a significant increase in KPS score after treatment (P<0.05), and there was a significant difference in the change in KPS score between the two groups (P<0.05). After treatment, the control group had significant reductions in the score of dry mouth/bitter taste (P<0.05) and significant increases in the scores of substernal burning pain and constipation (P<0.05), while the observation group had significant reductions in the scores of dry mouth/bitter taste, substernal burning pain, and constipation (P<0.05), and there were significant differences between the two groups in the changes in the scores of dry mouth/bitter taste, substernal burning pain, and constipation after treatment (P<0.05). The observation group had a significantly better treatment outcome than the control group (P<0.05). Conclusion Jiawei Simiao Yongan Decoction has a good clinical effect in the treatment of acute radiation esophagitis and can significantly improve clinical symptoms.