目的 探索孤独症谱系障碍（autism spectrum disorder，ASD）儿童中医证候分布规律，为中医诊治ASD的规范化提供理论依据。方法 采集陕西中医药大学附属医院、西安交通大学附属儿童医院共154例ASD患儿的一般情况及中医四诊资料，运用因子分析及聚类分析等多元统计学方法，确定ASD的中医证型并进行分布规律研究。结果 中医证型分布当中，占比从高到低依次为肝郁脾虚（43.51%）、心肝火旺（20.13%）、脾肺气虚（18.18%）、心脾两虚（13.64%）、肾精不足（2.60%）、脾肾阳虚（1.95%）。结论 ASD儿童中医临床证型以实证和虚实夹杂为主，肝郁脾虚、心肝火旺、脾肺气虚、心脾两虚为ASD的4个主要证候分型，肾精不足、脾肾阳虚证并不是ASD儿童的优势证型。
Objective To investigate the distribution of traditional Chinese medicine (TCM) syndromes in children with autism spectrum disorder (ASD), and to provide a theoretical basis for the standardization of the diagnosis and treatment of ASD. Methods General information and the data obtained by the four TCM diagnostic methods were collected from 154 children with ASD in The Affiliated Hospital of Shaanxi University of Chinese Medicine and Childrens Hospital Affiliated to Xi'an Jiaotong University, and multiple statistical methods including factor analysis and cluster analysis were used to determine the TCM syndrome types of ASD and investigate their distribution pattern. Results Among the TCM syndrome types of ASD, liver depression and spleen deficiency accounted for the highest proportion of 43.51%, followed by hyperactivity of heart-liver fire (20.13%), spleen-lung Qi deficiency (18.18%), deficiency of both heart and spleen (13.64%), insufficiency of kidney essence (2.60%), and spleen-kidney Yang deficiency (1.95%). Conclusion The clinical TCM syndrome types of ASD are mainly excess syndrome or intermingled deficiency and excess, and liver depression and spleen deficiency, hyperactivity of heart-liver fire, spleen-lung Qi deficiency, and deficiency of both heart and spleen are the four main syndrome types of ASD, while insufficiency of kidney essence and spleen-kidney Yang deficiency are not the dominant syndrome types in children with ASD.
马艳芳,郭亚雄,陈艳妮,王亚楠,耿亮亮 ,金 瑄,张 卉.154例孤独症谱系障碍儿童中医证候分布规律研究[J].安徽中医药大学学报,2022,41(5):43-47复制