三阳清解方联合穴位放血治疗流行性感冒疗效观察
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安徽省教育厅中医药防治肺系重大疾病重点实验室开放基金项目(JYTKF2020-8)


Clinical Effect of Sanyang Qingjie Prescription Combined with Blood-letting Therapy at Acupoints in Treatment of Influenza
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    摘要:

    目的 观察三阳清解方联合穴位放血治疗流行性感冒的临床疗效。方法 将45例流行性感冒患者随机分为治疗组23例,对照组22例。对照组予以重组人干扰素α和磷酸奥司他韦治疗,治疗组在对照组基础上加用三阳清解方联合穴位放血治疗。比较两组患者治疗前后症状评分、体温复常时间、核酸转阴率、白细胞计数、淋巴细胞比率、C-反应蛋白(C-reactive protein,CRP)、血清淀粉样蛋白A(serum amyloid A, SAA)水平。结果 治疗后两组患者咳嗽、咽痛、口渴、乏力、四肢酸痛评分均显著降低(P<0.05),两组患者淋巴细胞比率、CRP、SAA水平较治疗前降低(P<0.05),白细胞计数较治疗前升高(P<0.05);治疗组患者咳嗽、口渴、四肢酸痛评分下降程度显著大于对照组(P<0.05);治疗组白细胞计数升高程度,CRP、SAA水平降低程度均明显大于对照组(P<0.05),治疗组病毒抗原转阴率显著高于对照组(P<0.05),治疗组体温复常时间较对照组显著缩短(P<0.05)。结论 三阳清解方能有效改善临床症状,提高病毒核酸转阴率,降低淋巴细胞比率、SAA、CRP水平,提升白细胞数。

    Abstract:

    Objective To investigate the clinical effect of Sanyang Qingjie prescription combined with blood-letting therapy at acupoints in the treatment of influenza. Methods A total of 45 patients with influenza were randomly divided into treatment group with 23 patients and control group with 22 patients. The patients in the control group were given recombinant human interferon-α and oseltamivir phosphate, and those in the treatment group were given Sanyang Qingjie prescription combined with blood-letting therapy at acupoints in addition to the treatment in the control group. The two groups were compared in terms of traditional Chinese medicine (TCM) syndrome score before and after treatment, time to normalization of body temperature, nucleic acid clearance rate, leukocyte count, lymphocyte ratio, C-reactive protein (CRP), and serum amyloid A protein (SAA). Results After treatment, both groups had significant reductions in the scores of cough, throat pain, thirstiness, weakness, and ache in the extremities (P<0.05), significant reductions in lymphocyte ratio and levels of CRP and SAA (P<0.05), and a significant increase in leukocyte count (P<0.05). Compared with the control group, the treatment group had significantly greater reductions in the scores of cough,thirstiness, and ache in the extremities (P<0.05), a significantly greater increase in leukocyte count (P<0.05), and significantly greater reductions in the levels of CRP and SAA (P<0.05). The treatment group had a significantly higher clearance rate of viral antigen (P<0.05) and a significantly shorter time of temperature turn to normal than the control group (P<0.05). Conclusion Sanyang Qingjie prescription can effectively improve clinical symptoms, increase the clearance rate of viral nucleic acid, reduce the levels of lymphocytes, SAA, and CRP, and increase leukocyte count.

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刘 洋,郑彩霞,韩金花,童佳兵,李泽庚.三阳清解方联合穴位放血治疗流行性感冒疗效观察[J].安徽中医药大学学报,2021,40(5):32-36

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  • 在线发布日期: 2021-10-17