Objective To investigate the clinical effect of Tongdu Tiaoshen acupuncture combined with bloodletting therapy at meridian sinew nodal points in the treatment of post-stroke spastic paralysis. Methods A total of 60 patients with post-stroke spastic paralysis were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the control group were given Tongdu Tiaoshen acupuncture, and those in the treatment group were given bloodletting therapy at meridian sinew nodal points in addition to the treatment in the control group. Before and after treatment, National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological defects, modified Ashworth scale (MAS) was used to evaluate the spasticity of limbs, and Fugl-Meyer Assessment (FMA) was used to evaluate the degree of dyskinesia after stroke; clinical outcome was also observed after treatment. Results After treatment, both groups had significant reductions in NIHSS score and MAS grade (P<0.05) and a significant increase in FMA score (P<0.05), and compared with the control group, the treatment group had significantly greater reductions in NIHSS score and MAS grade (P<0.05) and a significantly higher FMA score (P<0.05). The treatment group had a significantly better clinical outcome than the control group (P<0.05). Conclusion Tongdu Tiaoshen acupuncture combined with bloodletting therapy at meridian sinew nodal points can significantly improve spasticity and motor function in patients with post-stroke spastic paralysis, with a better clinical effect than Tongdu Tiaoshen acupuncture alone.