Objective To investigate the clinical effect of Qihuang Jianpi Zishen Granule in the treatment of Sjgren's syndrome with deficiency of both Qi and Yin. Methods A total of 60 patients with Sjgrens syndrome with deficiency of both Qi and Yin were divided into treatment group and control group using a random number table, with 30 patients in each group. The patients in both groups were given oral administration of hydroxychloroquine sulfate tablets (at a dose of 0.1 g, twice a day) and methylprednisolone tablets (at a dose of 2 mg, once a day), and those in the treatment group were given Qihuang Jianpi Zishen Granule at a dose of 10 g, once a day; the course of treatment was 12 weeks for both groups. Traditional Chinese medicine (TCM) syndrome score was used to evaluate TCM clinical outcome after treatment; EULAR Sjgrens Syndrome Patient Reported Index (ESSPRI) and EULAR Sjgrens Syndrome Disease Activity Index (ESSDAI) were calculated to evaluate disease activity; related serological markers were measured before and after treatment to evaluate disease progression, including rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), complement 3 (C3), and complement 4 (C4). Results After 12 weeks of treatment, the treatment group had a significantly better clinical outcome than the control group (P<0.05), and compared with the control group, the treatment group had significantly greater reductions in the scores of dryness in the eyes, dry mouth and throat, dry skin, joint pain, salivary gland swelling, and body weakness and the ESSPRI and ESSDAI scores (P<0.05); after treatment, both groups had significant reductions in ESR and the serum levels of RF, CRP, IgG, IgA, and IgM (P<0.05) and significant increases in the levels of C3 and C4 (P<0.05). Compared with the control group, the treatment group had significantly greater reductions in RF, ESR, and IgG after treatment (P<0.05). Conclusion For patients with Sjgrens syndrome, Qihuang Jianpi Zishen Granule combined with basic therapy can effectively improve clinical symptoms, reduce the levels of ESR, IgG, and RF in peripheral blood, improve the bodys inflammatory response, effectively alleviate disease progression, and thus improve the clinical outcome after treatment.