固本清毒汤治疗宫颈高危型人乳头瘤病毒感染临床观察
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安徽中医药大学校级自然科学研究项目(2019fyyb23)


Clinical Effect of Guben Qingdu Decoction in Treatment of Cervical High-risk Human Papillomavirus Infection
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    摘要:

    目的 观察固本清毒汤治疗宫颈高危型人乳头瘤病毒(human papillomavirus, HPV)感染的疗效。方法 将60例宫颈高危型HPV感染患者随机分成治疗组和对照组,每组30例。治疗组予以干扰素片阴道纳药联合固本清毒汤内服,对照组仅予以干扰素片阴道纳药。观察两组患者治疗前后湿热瘀毒证积分变化,检测血清白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8, IL-8)水平和外周血CD3+、CD4+ T细胞亚群和CD4+/CD8+比值,比较两组中医证候疗效和HPV转阴率。结果 与治疗前比较,两组患者治疗后中医证候积分和血清IL-6、IL-8水平均显著降低(P<0.05);治疗组中医证候积分和血清IL-6、IL-8水平降低程度显著大于对照组(P<0.05),治疗组患者中医证候疗效显著优于对照组(P<0.05)。与治疗前比较,对照组患者仅CD3+ T细胞显著升高(P<0.05),治疗组患者CD3+、CD4+ T细胞和CD4+/CD8+比值均显著升高(P<0.05)。治疗组、对照组患者HPV转阴率分别为83.3%、60%,差异有统计学意义(P<0.05)。结论 固本清毒汤联合干扰素能明显改善宫颈高危型HPV感染患者湿热瘀毒证候,调节机体免疫功能,提高HPV转阴率。

    Abstract:

    Objective To investigate the clinical effect of Guben Qingdu Decoction in the treatment of cervical high-risk human papillomavirus (HPV) infection. Methods A total of 60 patients with cervical high-risk HPV infection were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given vaginal administration of interferon tablets combined with oral administration of Guben Qingdu Decoction, and those in the control group were given vaginal administration of interferon tablets alone. The change in the score of damp-heat stasis-toxin syndrome was evaluated after treatment, and the serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8), CD3+and CD4+ T lymphocyte subsets in peripheral blood, and CD4+/CD8+ ratio were measured. The outcome of TCM syndrome and HPV clearance rate were compared between the two groups.Results After treatment, both groups had significant reductions in TCM syndrome score and the serum levels of IL-6 and IL-8 (P<0.05), and the treatment group had significantly greater reductions than the control group (P<0.05); the treatment group had a significantly better outcome of TCM syndrome than the control group (P<0.05). After treatment, the control group had a significant increase in CD3+ T lymphocytes (P<0.05), and the treatment group had significant increases in CD3+and CD4+ T lymphocytes and CD4+/CD8+ ratio (P<0.05). There was a significant difference in HPV clearance rate between the treatment group and the control group (83.3% vs 60%, P<0.05). Conclusion In patients with cervical high-risk HPV infection, Guben Qingdu Decoction combined with interferon can significantly improve damp-heat stasis-toxin syndrome, regulate the bodys immune function, and increase HPV clearance rate.

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杨 璇,杜冰心,汪翠萍,方曾江楠.固本清毒汤治疗宫颈高危型人乳头瘤病毒感染临床观察[J].安徽中医药大学学报,2021,40(4):32-35

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  • 在线发布日期: 2021-08-14