新风胶囊治疗类风湿关节炎Meta分析
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国家重点研发计划项目(2018YFC1705204);安徽省重点研究和开发计划对外科技合作项目(201904b11020011);安徽省名中医刘健工作室建设项目(中医药发展秘〔2018〕11号)


Clinical Effect of Xinfeng Capsule in Treatment of Rheumatoid Arthritis: A Meta-analysis
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    摘要:

    目的 系统评价中药复方新风胶囊(Xinfeng Capsule, XFC)治疗类风湿关节炎(rheumatoid arthritis, RA)的临床疗效,为临床应用XFC治疗RA提供指导。方法 通过系统检索中国知网、万方数据、维普网以及PubMed、EMbase、Cochrane数据库,收集XFC治疗RA的随机对照试验,对照组干预措施为来氟米特,应用风险评估工具进行研究质量评价,采用RevMan 5.3软件对纳入文献提取的关节症状和免疫炎症指标进行Meta分析。结果 共检索到567篇文献,最终纳入10篇文献。Meta分析结果显示,与对照组相比,XFC组能显著改善关节疼痛(SMD=-1.50,95% CI为-1.69~-1.30,P<0.000 01)、肿胀(SMD=-1.03,95% CI为-1.52~-0.54,P<0.000 1)、晨僵时间(MD=-0.54,95% CI为-0.72~-0.37,P<0.000 01),降低血沉(SMD=-1.19,95% CI为-2.19~-0.19,P<0.000 01)、血清C-反应蛋白水平(SMD=-1.21,95% CI为-2.02~-0.41,P=0.003)、抗环瓜氨酸肽抗体(SMD =-0.79,95% CI为-1.36~-0.23,P=0.006)。结论 现有的证据表明XFC治疗RA具有确切疗效,能显著改善RA患者的关节症状及炎症指标,提高患者生活质量。

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    Objective To systematically evaluate the clinical effect of Xinfeng Capsule (XFC) in the treatment of rheumatoid arthritis (RA), and to provide guidance for the clinical application of XFC in the treatment of RA. Methods CNKI, Wanfang Data, VIP, PubMed, Embase, and Cochrane database were searched for randomized controlled trials (RCTs) of XFC in the treatment of RA, with leflunomide as the intervention in control group. Risk assessment tools were used to evaluate research quality, and RevMan 5.3 software was used to perform the meta-analysis of the joint symptoms and immune inflammation indices extracted from the articles included. Results A total of 567 articles were retrieved, among which 10 were included. The meta-analysis showed that compared with the control group, the XFC group had significant improvements in joint pain [standardized mean difference (SMD)=-1.50; 95% confidence interval (CI): -1.69 to -1.30; P<0.000 01), swelling (SMD=-1.03; 95% CI: -1.52 to -0.54;P<0.000 1), and morning stiffness time (mean difference=-0.54; 95% CI: -0.72 to -0.37; P<0.000 01), as well as significant reductions in erythrocyte sedimentation rate (SMD=-1.19; 95% CI: -2.19 to -0.19; P<0.000 01), serum C-reactive protein (SMD=-1.21; 95% CI: -2.02 to -0.41; P=0.003), and anti-cyclic citrullinated peptide antibody (SMD=-0.79, 95% CI: -1.36 to -0.23; P=0.006). Conclusion Current evidence shows that XFC has a marked clinical effect in the treatment of RA and can improve patients joint symptoms, inflammatory indices, and quality of life.

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文建庭,刘 健,孙艳秋,张 颖,杜新雷,王 馨,王 杰.新风胶囊治疗类风湿关节炎Meta分析[J].安徽中医药大学学报,2020,39(5):83-88

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  • 在线发布日期: 2020-10-15