热毒宁注射液治疗重症监护室肺部感染热毒蕴肺证临床研究
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Clinical Effect of Reduning Injection in Treatment of Pulmonary Infection with Heat Toxin Accumulating in Lung in the Intensive Care Unit
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    摘要:

    目的 探讨热毒宁注射液治疗重症监护室肺部感染患者的临床疗效。方法 将60例重症监护室肺部感染热毒蕴肺证患者随机分为治疗组和对照组,每组30例。两组均给予常规治疗,治疗组在常规治疗基础上给予热毒宁注射液,疗程7 d。比较两组疗效,治疗前后血清白细胞(white blood cell,WBC)计数、中性粒细胞(neutrophils,N)百分比、降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)水平,痰培养转阴率,急性生理与慢性健康评估Ⅱ(acute physiology and chronic health evaluation Ⅱ,APACHE Ⅱ)评分和中医证候评分。结果 两组患者临床疗效分布比较,差异有统计学意义(P<0.05)。两组治疗后WBC、N、PCT、CRP水平较治疗前明显降低(P<0.05),且治疗组上述指标降低程度显著大于对照组(P<0.05)。治疗组痰培养转阴率高于对照组,差异有统计学意义(P<0.05)。两组治疗后APACHEⅡ评分均较治疗前明显降低(P<0.05),治疗组较对照组降低更为明显(P<0.05)。两组治疗后中医证候积分均较前下降(P<0.05),治疗组较对照组下降更明显(P<0.05)。结论 热毒宁注射液可明显提高重症监护室肺部感染患者的临床疗效,改善相关炎症指标。

    Abstract:

    Objective To investigate the clinical effect of Reduning Injection in the treatment of patients with pulmonary infection in the intensive care unit (ICU). Methods A total of 60 patients with pulmonary infection with heat toxin accumulating in lung who were admitted to the ICU were enrolled and randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given conventional treatment combined with Reduning Injection, and those in the control group were given conventional treatment alone; the course of treatment was 7 days for both groups. Clinical outcome was compared between the two groups, as well as serum white blood cell count (WBC), neutrophil (N) percentage,procalcitonin(PCT), C-reactive protein(CRP), clearance rate of bacteria in sputum culture, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score, and traditional Chinese medicine (TCM) syndrome score before and after treatment. Results There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05). Both groups had significant reductions in WBC, N, PCT, and CRP after treatment (P<0.05), and the treatment group had significantly greater reductions than the control group (P<0.05). The treatment group had a significantly higher clearance rate of bacteria in sputum culture than the control group after treatment (P<0.05). Both groups had a significant reduction in APACHEⅡ score after treatment (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05).Both groups had a significant reduction in TCM syndrome score after treatment (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05). Conclusion Reduning Injection can significantly improve the clinical outcome and inflammatory indices of patients with pulmonary infection in the ICU.

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王玉玉,周大勇,王良慧,张 瑜,卢 勇,周 璇.热毒宁注射液治疗重症监护室肺部感染热毒蕴肺证临床研究[J].安徽中医药大学学报,2020,39(5):12-15

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  • 在线发布日期: 2020-10-15