Abstract:Objective To investigate the clinical effect of Reduning Injection in the treatment of patients with pulmonary infection in the intensive care unit (ICU). Methods A total of 60 patients with pulmonary infection with heat toxin accumulating in lung who were admitted to the ICU were enrolled and randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given conventional treatment combined with Reduning Injection, and those in the control group were given conventional treatment alone; the course of treatment was 7 days for both groups. Clinical outcome was compared between the two groups, as well as serum white blood cell count (WBC), neutrophil (N) percentage,procalcitonin(PCT), C-reactive protein(CRP), clearance rate of bacteria in sputum culture, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score, and traditional Chinese medicine (TCM) syndrome score before and after treatment. Results There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05). Both groups had significant reductions in WBC, N, PCT, and CRP after treatment (P<0.05), and the treatment group had significantly greater reductions than the control group (P<0.05). The treatment group had a significantly higher clearance rate of bacteria in sputum culture than the control group after treatment (P<0.05). Both groups had a significant reduction in APACHEⅡ score after treatment (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05).Both groups had a significant reduction in TCM syndrome score after treatment (P<0.05), and the treatment group had a significantly greater reduction than the control group (P<0.05). Conclusion Reduning Injection can significantly improve the clinical outcome and inflammatory indices of patients with pulmonary infection in the ICU.