益气温阳活血利水法治疗慢性心力衰竭疗效观察
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安徽中医药大学自然科学研究一般项目(2017fyy020)


Clinical Effect of Qi-tonifying, Yang-warming, Blood-activating, and Diuresis-inducing Therapy in Treatment of Chronic Heart Failure
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    摘要:

    目的 观察益气温阳活血利水法治疗慢性心力衰竭的临床疗效。方法 将40例慢性心力衰竭患者,随机分为治疗组和对照组,每组20例。对照组采用常规西医药物治疗,治疗组在对照组治疗的基础上加用益气温阳活血利水方口服。治疗前后分别观察两组患者左室舒张末内径(left ventricular diastolic dimension, LVDd)、左室射血分数(left ventricular ejection fraction, LVEF)、血浆B型脑利钠肽前体(N-terminal pro-B-type natriuretic peptide, NT-proBNP)、外周静脉压(peripheral venous pressure,PVP)、6 min步行距离(6-minute walk test, 6MWT)。结果 与治疗前比较,两组患者治疗后NT-proBNP、PVP、LVDd均显著降低(P<0.05),LVEF、6MWT均显著升高(P<0.05);治疗组患者治疗后NT-proBNP、PVP降低程度和LVEF、6MWT升高程度均显著大于对照组(P<0.05)。结论 益气温阳活血利水法能改善慢性心力衰竭患者的心功能指标,改善患者心功能。

    Abstract:

    Objective To investigate the clinical effect of Qi-tonifying, Yang-warming, blood-activating, and diuresis-inducing therapy in the treatment of chronic heart failure. Methods A total of 40 patients with chronic heart failure were randomly divided into treatment group and control group, with 20 patients in each group. The patients in the control group were given conventional Western medicine treatment, and those in the treatment group were given oral administration of Qi-tonifying, Yang-warming, blood-activating, and diuresis-inducing prescription in addition to the treatment in the control group. Left ventricular diastolic dimension (LVDd), left ventricular ejection fraction (LVEF), plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP), peripheral venous pressure (PVP), and 6-minute walk test (6MWT) were observed before and after treatment. Results After treatment, both groups had significant reductions in NT-proBNP,PVP, and LVDd (P<0.05) and significant increases in LVEF and 6MWT (P<0.05), and compared with the control group, the treatment group had significantly greater reductions in NT-proBNP and PVP and increases in LVEF and 6MWT (P<0.05). Conclusion Qi-tonifying, Yang-warming, blood-activating, and diuresis-inducing therapy can improve cardiac function parameters in patients with chronic heart failure.

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邓 坤,周 婧,李广兵,朱 涛,章 燕,丁 丽.益气温阳活血利水法治疗慢性心力衰竭疗效观察[J].安徽中医药大学学报,2020,39(4):27-30

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  • 在线发布日期: 2020-08-01