目的 观察消瘤止痛散外敷阿是穴缓解癌性疼痛的临床疗效。方法 将66例中度癌性疼痛患者，按随机数字表法分为治疗组和对照组各33例。治疗组采用消瘤止痛散外敷阿是穴治疗，对照组采用口服盐酸曲马多缓释片治疗。两组连续治疗7 d为1个疗程，比较两组治疗前后疼痛缓解情况、止痛起效时间、止痛持续时间、不良反应和生活质量。结果 两组患者基于视觉模拟量表评分的止痛效果比较，差异有统计学意义（P＜0.05），治疗组在缓解疼痛方面明显优于对照组；与对照组比较，治疗组止痛起效时间明显延迟（P＜0.05），但止痛持续时间明显延长（P＜0.05）；与治疗前比较，两组患者治疗后体力状况（performance status, PS）评分均显著降低（P＜0.05）；两组患者治疗后PS评分变化比较，差异有统计学意义（P＜0.05），治疗组患者PS评分改善程度显著优于对照组；与对照组相比，治疗组不良反应少，仅有2例患者发生轻度皮肤反应。结论 消瘤止痛散外敷阿是穴能有效减轻癌性疼痛，改善患者的生活质量，且不良反应小。
Objective To investigate the clinical effect of external application of Xiaoliu Zhitong Powder at Ashi point in the treatment of cancer pain. Methods A total of 66 patients with moderate cancer pain were divided into treatment group and control group using a random number table, with 33 patients in each group. The patients in the treatment group were given the external application of Xiaoliu Zhitong Powder at Ashi point, and those in the control group were given oral tramadol hydrochloride sustained-release tablets. Each course of treatment was 7 days, and the two groups were compared in terms of pain relief after treatment, onset time of pain relief, duration of pain relief, adverse events, and quality of life. Results There was a significant difference in the outcome of pain relief based on Visual Analog Scale between the two groups (P<0.05), and the treatment group had significantly better pain relief than the control group. The treatment group had significantly longer onset time of pain relief and duration of pain relief than the control group (P<0.05). Both groups had a significant reduction in performance status (PS) score after treatment (P<0.05), and the treatment group had a significantly greater improvement in PS score than the control group (P<0.05). Compared with the control group, the treatment group had fewer adverse events, with mild skin reaction in 2 patients. Conclusion External application of Xiaoliu Zhitong Powder at Ashi point can effectively alleviate cancer pain and improve patients quality of life, with few adverse events.
苏 丽,张兴龙,郑 磊,朱治法,张 梅.消瘤止痛散外敷阿是穴治疗癌性疼痛临床观察[J].安徽中医药大学学报,2020,39(2):32-35复制