补肾活血法联合西药治疗骨转移癌疼痛25例
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湖南省教育厅重点项目(15A139);湖南省研究生科研创新项目(CX2016B355)


Clinical Effect of Kidney-tonifying and Blood-activating Method Combined with Western Medicine in Treatment of Bone Metastasis Pain
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    摘要:

    目的 观察补肾活血法联合西药治疗骨转移癌疼痛的疗效和安全性。方法 将50例骨转移癌疼痛患者按随机数字表法分为两组,对照组(25例)采用盐酸羟考酮缓释片联合唑来膦酸注射液治疗,治疗组(25例)在对照组基础上加用补肾活血法组方的中药,观察比较两组患者疼痛、骨转移病灶疗效,生活质量,骨转移无进展时间,骨转移后总生存时间(bone metastasis-overall survival,BM-OS)及不良反应。结果 治疗组疼痛、骨转移病灶疗效均优于对照组(P<0.05)。治疗后两组患者生活质量均较治疗前明显改善(P<0.05),其中日常活动、情绪、人际关系和睡眠方面与对照组比较,治疗组患者改善更明显,差异均具有统计学意义(P<0.05)。治疗后治疗组骨转移无进展时间及BM-OS均较对照组延长,差异有统计学意义(P<0.05)。两组不良反应均可耐受。结论 补肾活血法联合西药治疗骨转移患者,具有更好的止痛、改善生活质量、延长无进展时间及生存期的作用。

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    Objective To investigate the clinical effect and safety of kidney-tonifying and blood-activating method combined with Western medicine in the treatment of bone metastasis pain. Methods A total of 50 patients with bone metastasis pain were divided into two groups using a random number table. The 25 patients in the control group were treated with oxycontin hydrochloride sustained-release tablets combined with zoledronic acid injection, and the 25 patients in the treatment group were treated with the kidney-tonifying and blood-activating prescription in addition to the treatment for the control group. The pain, clinical outcome of bone metastatic lesions, quality of life, bone metastasis progression-free survival, bone metastasis-overall survival (BM-OS), and adverse events were observed and compared between the two groups. Results The treatment group had significantly better improvements in pain and clinical outcome of bone metastatic lesions than the control group (P<0.05). Both groups had a significant improvement in quality of life after treatment (P<0.05), and the treatment group had significantly better improvements in daily activity, emotion, interpersonal relationship, and sleep compared with the control group (P<0.05). After treatment, the treatment group had significantly longer bone metastasis progression-free survival and BM-OS than the control group (P<0.05). All the patients were tolerant to adverse events. Conclusion In patients with bone metastasis, the kidney-tonifying and blood-activating method combined with Western medicine has a better pain-relieving effect and can improve quality of life and prolong progression-free survival and survival time.

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陈州华,黄立中,肖玉洁,周胜涟,徐 婪,丁 佩.补肾活血法联合西药治疗骨转移癌疼痛25例[J].安徽中医药大学学报,2016,35(6):22-26

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  • 在线发布日期: 2016-12-03