Objective:To probe into the mechanism on non insulin dependent diabetes mellitus (NIDDM) by observing the clinical therapeutic effect of acupuncture.Method:67 cases of NIDDM were divided into four types by differentiation of syndromes for NIDDM as follows:Heat excess in spleen and stomach(34 cases),accumulation of dampness due to deficiency of spleen Qi(13 cases),stagnation of liver Qi(12 cases),kidney Qi deficiency(8 cases),and treated by reinforcing reducing manipulation accordingly.The level of blood glucose,insulin and lipid were measured before and after treatment at the same time.Result:Acupuncture can ameliorate blood glucose and lipid metabolism as well as the clinical symptoms and obesity indexes.